Hylexin Clinical
0.78 fl. oz. for $95
Category:Skin Care > Retinol Products > Eye Moisturizers
Last Updated:02.11.2014
Jar Packaging:No
Tested on animals:No
Review Overview

Although it contains some state-of-the-art ingredients that make it worthwhile as a lightweight moisturizer, none of them can affect the oxidation of hemoglobin in capillaries lying beneath the surface of the skin in the eye area (or anywhere else), nor do they have an impact on the enzyme activity that supposedly controls this function, as claimed. The ingredient associated with this potential effect is the citrus bioflavonoid called hesperidin methyl chalcone. There is research supporting its internal use as an aid to venous (vein) problems. One study documented that it lowers the filtration rate of capillaries; less blood flowing though capillaries close to the surface of skin potentially means less hemoglobin would oxygenate to cause a dark bluish discoloration under the eyes. However, there is no substantiated research proving that hesperidin methyl chalcone will have this effect when applied topically.

Another study detailed this ingredient’s use when combined with the root of the Ruscus aculeatus plant and vitamin C, but again it was about oral consumption for alleviating symptoms of varicose veins and helping prevent them from becoming a chronic disease (Source: International Angiology, September 2003, pages 250–262). It is clear from published research that hesperidin methyl chalcone does have various benefits for the body, but diminishing severe dark circles via topical application is not one of them (Source www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/hes_0295.shtml) Although hesperidin methyl chalcone cannot affect blood vessels when applied topically (Source: www.naturaldatabase.com), as a bioflavonoid, it has antioxidant and anti-inflammatory properties, so it is still a potentially good ingredient for skin, provided you aren’t hoping for a dark circle–eliminating miracle. Hylexin is fragrance-free.


Formulated to help reduce the appearance of serious dark circles and chronic puffiness surrounding the orbital eye area. In clinical studies, Hylexin has been shown to help reduce hemoglobin degradation by-products by optimizing enzymatic activity, causing the red-blue pigmentation of dark circles to fade. Studies also confirm that Hylexin actually helps strengthen the capillary matrix to help stop the "leaking," so the delicate skin in the orbital eye area is protected against further damage.


Water, Glycerin, Cyclopentasiloxane, Silica, Cetyl Alcohol, Gynostemma Pentaphyllum Extract, Helianthus Annuus (Sunflower) Seed Oil, Polyglyceryl-3 Beeswax, Stearic Acid, Dipeptide-2, Palmitoyl Oligopeptide, Chrysin, Palmitoyl Tetrapeptide-3, Hydroxysuccinimide, Hesperidine Methyl Chalcone, Steareth-20, Polysilicone 11, Chlorhexidine Digluconate, Potassium Sorbate, Triethanolamine, Phenoxyethanol, Methylparaben, Butylparaben, Ethylparaben, Propylparaben, Isobutylparaben

Brand Overview

Bremenn Clinical At-A-Glance

Strengths: Good Moisturizer for night use, pricey products

Weaknesses: Moisturizer does not contain sunscreen, Nothing can fix sagging skin once it begins to droop.

Please see our product reviews for complete details. For more information about Bremenn Clinical, please visit www.bremennlabs.com.

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