MetroGel 1% is similar to MetroGel 0.75%, except the base formula contains a tiny amount of the cell-communicating ingredient niacinamide. This higher concentration of metronidazole is recommended for use once per day. Promotional materials for this drug mention the term betadex. This ingredient is based around b-cyclodextrin, which is derived from starch and enhances penetration of the active ingredient into the skin. This has the potential to be a very effective topical prescription for controlling the symptoms of rosacea.
These three prescription-only drugs are topical applications used to treat rosacea. They contain the active ingredient metronidazole, an antimicrobial agent thought to combat the cause of rosacea. For many patients dealing with this skin disorder, this is in fact an optimal way to treat rosacea, because it helps minimize the redness, papules, and pustules that accompany this condition. It is considered the place to start when putting together an effective skin-care program to manage rosacea (Sources: Cutis, January 2007, pages 73–80; Skin Therapy Letter, March 2006, pages 1–4; Journal of Drugs in Dermatology, January 2006, pages 23–26; and Journal of Cutaneous Medicine and Surgery, May 13, 2002). As another option, metronidazole is also found in the prescription-only topical drug Noritate.
For more information, call (866) 735-4137 or visit the Web site at www.metrogel.com.
Note: If metronidazole does not work for you, talk to your dermatologist about other prescription options for rosacea, including azelaic acid (Finacea), oral antibiotics such as tetracycline and its derivatives, and topical products containing sulfur (though these tend to be the most irritating and drying and should be considered a last resort, assuming your skin can tolerate this ingredient at all).