Tested on animals:No
Lots of you have been asking about Nerium AD's treatment cream, possibly because you know someone who sells it or perhaps you stumbled across web sites selling it while searching for anti-aging skin care online. However you found out about it, we're here to tell you to forget about it. Nerium AD Age-Defying Night Cream (formerly labeled as Age Defying Treatment) is not the anti-wrinkle answer. It's also not the solution for hyperpigmentation, sagging skin, uneven skin tone, or enlarged pores.
As the story (often) goes, the key ingredient in this cream (a plant known as Nerium oleander) was being researched for other purposes when it was discovered to have so-called miraculous skin care benefits. The company behind this product (Texas-based Nerium International) didn't need long to realize they could use this discovery to get a toehold in the burgeoning anti-aging skin care market, and thus another allegedly amazing anti-wrinkle product with "real results" was born.
Nerium International is a direct sell, multi-level marketing business, which means you can sign up to sell Nerium AD to others (friends, family, co-workers) and then recruit these people to be part of your team, where you earn a portion of their commission. These "brand partners" are paid commission and can earn incentives (like a free iPad) for their sales, similar to the business model of brands such as Amway (Quixtar). There's nothing wrong with selling product this way, if what you're selling is worth buying!
Nerium International debuted with one skin-care product, which is the topic of this review, but they've since expanded a bit. Their core product is supposedly for all skin types, and, for the most part, the ingredient list bears that out. But the ingredient list also makes a few mistakes in terms of how ingredients are disclosed. For example, "NAE-8"; is a trademarked ingredient blend that contains aloe and the allegedly superior nerium oleander leaf. Those ingredients should be listed by themselves, not preceded by "NAE-8";—but it does make the formula seem more technical and special. Other than Nerium oleander leaf (discussed below) this serum's ingredients are fairly commonplace: aloe, some skin-repairing ingredients, slip agent, plant oil, several thickeners, preservatives, fragrance, and vitamin E.
Although the product will hydrate and make skin feel smoother and softer, so will countless other skin-care products that don't have Nerium AD's price tag or unsupported claims. Also, please know that the collagen and elastin in this product cannot fuse with or shore up these substances in your skin. They simply do not work this way, nor would you want them to (because over time you'd be applying enough collagen and elastin to leave you with lumpy, uneven skin where areas had too much collagen and elastin built).
Back to Nerium oleander leaf: it's poisonous and potentially fatal if consumed orally, which isn't how this product should be used but using any plant on your face with that kind of toxic profile should give you pause. Specific to topical use, there is no published, independent, substantiated research proving this plant extract has any special or unique properties for aging skin, uneven skin tone, or large pores. There was one animal study showing oleander's anti-inflammatory benefit, but lots of plants offer this benefit without the risks involved with oleander. And Nerium sponsored a study comparing its plant extract with aloe, the results of which showed Nerium oledander was a better, more multi-faceted antioxidant (Source: Clinical, Cosmetic, and Investigational Dermatology, May 2015, pages 239-248). That's interesting but MANY antioxidants are more powerful than aloe. We'd love to know how Nerium AD's allegedly miraculous plant compares to more established antioxidants like green tea and resveratrol.
Other research has shown that Nerium oleander leaf is a potent insecticide and it interrupts the cellular process known as mitosis, a process of cellular division that affects the body's chromosomes. None of this is appealing when we're talking skin care and the risks involved make nerium oleander a plant to leave off your skin (Sources: Toxicology and Applied Pharmacology, March 2004, pages 361-369; Veterinary and Human Toxicology, February 1999, pages 9–15; and www.naturaldatabase.com).
Bottom line: although this product contains some beneficial ingredients, what makes it unique is also what makes it potentially problematic—and there is no reliable, independent research to support the wonderful things that plant is said to do for skin. If you want the anti-aging benefits of plants, there are many others to choose from that don't have much better safety and, even better, skin-improving profiles.
More information explaining the problems nerium oleander presents can be found here.