Serum Presse is, quite simply, the serum version of ReVive’s Les Yeux (eye) Presse. Unlike the eye-area version, Serum Presse omits the fragrant orange fruit water, which is good news. The bad news is that the formula contains pure orange oil and some volatile fragrance chemicals, although their presence is minor.
Overall, this is an exceedingly overpriced “moisturizer” that cannot live up to its lifting claims. It would be wonderful if there really were a face-lift in a bottle, but skin-care products cannot address the multiple factors that lead to skin sagging and gradual laxity. This serum will make skin appear smoother, and the film-forming agent (think hairspray) can cause a temporary firm feel, but no lifting is taking place, so the effect is strictly cosmetic.
ReVive includes some antioxidants and cell-communicating ingredients, but the main point of difference this brand has is its use of growth factors. The ones used in this serum are epidermal growth factor (EGF) and fibroblast growth factor (FGF; fibroblasts are specialized cells that generate skin’s collagen). There is no research proving topical application of these growth factors can firm or lift skin, but there is no research proving otherwise either.
Topical application of growth factors is controversial for many reasons (see the brand summary of ReVive that we include in our review for detailed information), but the primary concern is that they may stimulate the proliferation of cells to the point where their normal, healthy growth goes haywire. Such uncontrolled growth is the blueprint for cancer, and that’s not a good tradeoff for lifted skin (which this product doesn’t provide).
It is somewhat loosely reassuring to discover that growth factors are not expected to have much, if any, effect when applied topically, because, according to the textbook Cosmetic Dermatology (2nd Edition, 2009, by Dr. Leslie Baumann MD), it is unknown if growth factors in skin-care products “are stable, can be absorbed adequately, or exert a functionally significant outcome to induce dermal remodeling and reverse photoaging” due to the lack of well-controlled studies. Still, it is precisely the unknowns surrounding topical application of various growth factors that warrant a cautionary approach to their use, if you even use them at all.
By the way, the glow this product provides is a cosmetic brightening effect, courtesy of standard cosmetic pigments. This product is neither special nor worth the price ReVive charges, but there you have it.
Instant gratification in a bottle. RéVive Serum Presse is the first RéVive serum to give skin the look of instant lift and radiance. Noticeably lifts and firms the skin immediately with an advanced polysaccharide tensor while brightening soft-focus optics give skin an instant glow. EGF along with FGF work over time to visibly improve skin’s loss of firmness and radiance. Skin looks instantly firmer, brighter, and younger.
Water, Butylene Glycol, Isotridecyl Isononanoate, Pentaerythrityl Tetracaprylate/Tetracaprate, Boron Nitride, Sodium Polyacrylate, Hydroxyethyl Urea, Diglycerin, Recombinant EGF, Recombinant FGF, Glycerin, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Avena Sativa (Oat) Kernel Extract, Squalane, Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, Tocopheryl Acetate, Bisabolol, Caffeine, Siloxanetriol Alginate, Centella Asiatica Extract, Ethylhexyl Palmitate, Silica Dimethyl Silylate, Sodium Hyaluronate, Sodium Bicarbonate, Xanthan Gum Crosspolymer, Hydrogenated Polydecene, Trideceth-6, Disodium EDTA, Ethylene/Acrylic Acid Copolymer, Glyceryl Polyacrylate, Phenoxyethanol, Caprylyl Glycol, Chlorphenesin, Citral, Limonene, Linalool, Citrus Aurantium Dulcis (Orange) Peel Oil, Mica, Talc, Titanium Dioxide, Alumina, Silica
Without a doubt, the founder of ReVive, Dr. Gregory Bays Brown, has some impressive credentials. He is a board-certified general and plastic surgeon who trained at Vanderbilt, Harvard, and Emory Universities, and received his medical degree from the University of Louisville. Realizing there was considerable money to be made in the realm of doctor-designed skin care, he launched the ReVive brand in the late 1990s, and it is now known as "A Plastic Surgeon's Non-Surgical Approach to Beauty."
It is nothing less than perplexing that there are so many doctors, from Fredric Brandt to N.V. Perricone, Drs. Murad and Sobel, and Patricia Wexler, to name a few, all claiming that their skin-care products are the answers for aging consumers who are concerned about "going under the knife" or about making an appointment that involves use of a needle. Can every doctor cure your wrinkles? And which one is telling the truth? Simply put: None of them. What they are doing, to one degree or another, is misleading the consumer as to what their products can really do, and every physician on the planet knows this to be a fact.
Brown does have one point of difference from his competition because he is the only one who uses growth factors (GF) in all his products. He was originally all about Epidermal Growth Factor (EGF), explained below, but now also offers products with Insulin-like Growth Factor (IGF) and Keratinocyte Growth Factor (KGF), each explained in their respective product reviews. With all the company's talk about speeding up cellular renewal via growth factors and promises of luscious, dewy, youthful-looking skin, you may be wondering if this is a group of ingredients worth paying (a lot of money) for.
Growth factors are produced by the body to regulate various types of cell division. EGF stimulates cell division, primarily cell division of skin cells. There is quite a bit of research showing EGF to be helpful for wound and burn healing (Sources: Journal of Burn Care and Rehabilitation, March-April 2002, pages 116–125; Journal of Dermatologic Surgery and Oncology, July 1992, pages 604–606; Journal of Anatomy, July 2005, pages 67–78; International Wound Journal, June 2006, pages 123–130;and Tissue Engineering, January 2007, pages 21–28).
However, there is also research showing the effect EGF has is no different from that of a placebo, that it may not be effective at all, and that too much of it can actually prolong healing (Sources: Wounds, 2001, volume 13, number 2, pages 53–58; and Plastic and Reconstructive Surgery, August 1995, pages 251–254, and September 1997, pages 657–664).
One study showed that EGF had anti-inflammatory properties when applied to skin (Source: Skin Pharmacology and Applied Skin Physiology, January-April 1999, pages 79–84), though it has also been noted that it may promote tumor growth (Source: Journal of Surgical Research, April 2002, pages 175–182).
In general, the potentially frightening consequences of growth factors can come into play when they are taken internally, as in certain cancer treatments (Interleukin and Interferon are GFs), because they can be highly mitogenic (causing cell division), and at certain concentrations and lengths of application can cause cells to overproliferate. This overabundance of cells causes problems, one result of which is cancer. No one is exactly certain what happens when EGFs are applied to healthy, intact skin, but there is concern that with repeated use EGFs can cause skin cells to overproduce, and that's not good (psoriasis is an example of what happens when skin cells overproduce).
All of the research that does exist on EGFs has primarily studied their short-term use for wound healing. ReVive's products aren't about wound healing or short-term use, but rather about ongoing application for wrinkles, and working against the reduced cell-turnover rate that occurs as we age. Moreover, what established research has shown (including most of the sources mentioned above) is that growth factors, including EGF, do not work alone. Rather, their function is part of an intricate symphony that requires the playing of several "notes" for the "concert" to be a success. Adding a tiny amount of EGF to skin-care products in the hopes that it will work like it does when applied to a wound is sort of like thinking you can frame a house with wood and use nothing to hold the beams together except wishful thinking. We suspect the EGFs that Brown uses are most likely not the active form of the "drug," because if they were the risk to skin would be scary (and the company admits the ingredient is engineered in a lab, which means it's not identical to the naturally occurring EGF).
For more information about ReVive, call 1-866-986-7083 or visit www.reviveskincare.com.