C E Ferulic Combination Antioxidant Treatment

$153 - 1 fl. oz.
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C E Ferulic Combination Antioxidant Treatment comes complete with all manner of anti-aging claims, but the only ones you can bank on with this product (based on a significant amount of research) are its abilities to reduce free radicals and to defend skin against oxidative stress. It reportedly contains 15% L-ascorbic acid, a form of vitamin C considered an excellent antioxidant and anti-inflammatory agent (Sources: Experimental Dermatology, June 2003, pages 237–244; and Bioelectrochemistry and Bioenergetics, May 1999, pages 453–461).

Because L-ascorbic acid is stable only in low-pH formulations (Source: Dermatologic Surgery, February 2001, pages 137–142), the good news is that this product’s pH of 3 is low enough to allow this form of vitamin C to be effective. Also present in this water-based antioxidant serum are vitamin E and ferulic acid. Vitamin E, appearing here as alpha tocopherol, also has a well-established reputation as an effective antioxidant (Sources: Radiation Research, July 2005, pages 63–72; Annals of the New York Academy of Sciences, December 2004, pages 443–447; and Journal of Investigative Dermatology, February 2005, pages 304–307).

Ferulic acid is relatively new to the skin-care scene, but earlier research suggests that it provides antioxidant and sun-protective benefits to skin while enhancing the stability of topical applications of vitamin E (Sources: International Journal of Pharmaceutics, April 10, 2000, pages 39–47; Anticancer Research, September–October 1999, pages 3769–3774; Nutrition and Cancer, February 1998, pages 81–85; and Free Radical Biology and Medicine, October 1992, pages 435–448). As research into this and similar compounds (such as caffeic and ellagic acid) continues, we suspect we will see more antioxidant-based products enhanced with them, which is great news for keeping skin healthy and protecting it from further damage.

C E Ferulic Combination Antioxidant Treatment is suitable for all skin types.

Note: This serum is dispensed via a dropper applicator. Although not the ideal method to dispense a serum that contains light- and air-sensitive ingredients, sometimes this type of packaging is necessary due to formulary requirements. When that’s the case, the goal is to keep the bottle opening as small as possible, the bottle should be opaque or specially coated to protect the contents from light, and you should use the serum up within three months of opening.


Combines proven antioxidant vitamins C & E with ferulic acid to maximize antioxidant performance. This synergistic formulation enhances protection against damaging UVA/UVB rays to better prevent premature signs of aging, while stimulating collagen production to help diminish the appearance of photo damage.

Water, Ethoxydiglycol, L Ascorbic Acid, Propylene Glycol, Glycerin, Laureth 23, Alpha Tocopherol, Phenoxyethanol, Triethanolamine, Ferulic Acid, Panthenol, Sodium Hyaluronate

With a strong presence in the professional (meaning spa and aesthetics) skin-care market, SkinCeuticals has a mostly well-deserved reputation for producing serious-minded, research-driven products, several of which are centered on L-ascorbic acid. Company founder Dr. Sheldon Pinnell began the line after a falling out with the folks behind Cellex-C, a company for which Dr. Pinnell once served as spokesperson. The falling out had to do with both Cellex-C and Dr. Pinnell holding patents on L-ascorbic acid; Cellex-C held the patent on a formula with L-ascorbic acid (the original Cellex-C serum) while Dr. Pinnell's patent (now conspicuously absent from SkinCeuticals products) was only for the ingredient. The drama continued as, years later, the doctor who joined Pinnell to work on SkinCeuticals' vitamin C products began his own company, also selling products with vitamin C. Who needs Desperate Housewives when we have desperate doctors racing to be the authoritative word on the anti-aging properties of vitamin C?

The good news is that copious research has demonstrated that L-ascorbic acid (despite its stability issues, which, formula-wise, SkinCeuticals products do address) is a good, potent antioxidant and anti-inflammatory agent. It has also been shown to provide photoprotective benefits when skin is exposed to UV light and is capable of stimulating collagen production - though don't take that to mean it is a cure for wrinkles (Sources: International Journal of Toxicology, 2005, supplement, pages 51–111; Experimental Dermatology, June 2003, pages 237–244; Dermatologic Surgery, March 2002, pages 231–236; Bioelectrochemistry and Bioenergetics, May 1999, pages 453–461; and International Journal of Radiation Biology, June 1999, pages 747–755). Of course, other forms of vitamin C have equally impressive research, and some forms, such as magnesium ascorbyl phosphate, have better stability profiles (Source: Journal of Pharmaceutical and Biomedical Analysis, March 1997, pages 795–801).

As we've mentioned before, vitamin C is but one of many good antioxidants, and it's not the best approach to select any one or two antioxidants and bank on them alone to provide every conceivable skin-rejuvenating benefit. Instead, go for products that offer a cocktail of antioxidants because you'll get a greater range of benefits. Plus, some antioxidants in combination have a synergistic effect that surpasses what occurs when any of the ingredients are used alone. SkinCeuticals clearly knows this, because their vitamin C products also contain the antioxidant ferulic acid, and some add vitamin E to the mix as well. Above all, remember that as multifunctional as antioxidants are, they cannot stop aging, they won't eliminate wrinkles, and they do not replace the need for daily sun protection.

L'Oreal purchased SkinCeuticals in May 2005, and, for the time being, seems to be letting them stay on their course. That's a good thing, because despite L'Oreal’s considerable financial reserves and global R&D team, the skin-care products their brands produce consistently lag behind what current research indicates are state-of-the-art options. As long as they continue to let SkinCeuticals retain its stature, there are many good reasons to shop this line; however, that said, this line is far from perfect in terms of being able to assemble a complete skin-care routine. Focusing on what they do best (which is serums, sunscreens, and specialty products) will be money well spent for visible results. Those who find the SkinCeuticals price tags to be a deal-breaker need to know that despite several notable products, they're hardly the only game in town; you can find equally superior products for less money, though not all of them follow the impressive concentration protocols of SkinCeuticals.

For more information about SkinCeuticals, call 1-800-771-9489 or visit www.skinceuticals.com.

Member Comments

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  1. How would you rate the results? (4 = Best)

    4 / 4 Best
  2. Was this product a good value? (4 = Best)

    3 / 4 Good
  3. Would you recommend this product? (4 = Best)

    4 / 4 Best
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  1. rain
    Reviewed on Sunday, November 24, 2013
    • Results
      4 / 4
    • Recommend
      4 / 4
    • Value
      3 / 4
    best serum
    • I have been using this serum now for 3 years and love it! everyone compliments me and I believe its all to do with the vitamin C I have been using for 13 years consistently on my face every morning. for 10 years I used cellex C , which was good but did some research on the company and skincueticals and the scientists and bumped it up an notch and started using this serum took my c serum and skin to another level... it is pricey but worth every penny.

  2. Anonymous
    Reviewed on Friday, April 26, 2013
    • Results
      4 / 4
    • Value
      4 / 4
    • Recommend
      4 / 4
    • Best of the best today's mkt. I have used 5 years. Of note ; I recently had co2 on a facial section. after the 3rd healing day, they added this in protocol as the first thing to put on face in AM after light cleansing---- whether or not going outdoors, the idea being it expedites healing process. I assumed it due to perhaps anti inflammant aspects.

  3. Lani
    Reviewed on Sunday, December 23, 2012
    • Value
      4 / 4
    • Recommend
      4 / 4
    • Results
      4 / 4
    Best CE Ferulic antioxidant on the Market IMOP!
    • Around the age of 29yrs old I started to get a mild form of eczema in Las Vegas. I'm an island girl from Hawaii and never had a problem with having dry skin as where the weather there was humid and I had oily skin due to being part Asian. Well having moved to the states my skin started becoming dry at almost the age of 30. I went to Green Valley Ranch spa, which had been voted numerous times as the best Spa in Las Vegas. They used the skinceuticals line and recommended the only thing I'd need would be CE ferulic. Upon that I decided to do my research before spending such a high price. The following month I went to the Hard Rock spa and well what do you know. They used and also said CE ferulic is the one thing that will help my dry and sensitive skin. I decided to go online and purchase the travel sizes of 6 small bottles that wer $35 which last longer since you don't expose all of it to oxygen, also it adds up to 1oz which is $148 for that size in the regular bottle. I've been using this faithfully for the past five years and I literally look 26yrs which is 9 years younger than what I am. I've recently found a product that is claimed to be just as good at only $28 called Mad Hippie. It is not reviewed on this site, but so far I use it though over my CE ferulic. The ingredients are similar to skinceuticals, but I'm still in the trial process of it. It has been seen in magazines and on Doctor OZ recommended by several cosmetic surgeons. I do hope it proves to work, as where it is literally 80% less the cost.

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About the Experts

Paula Begoun is the best-selling author of 20 books on skin care and makeup. She is known worldwide as the Cosmetics Cop and creator of Paula's Choice. Paula's expertise has led to hundreds of appearances on national and international television including:

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The Paula's Choice Research Team is dedicated to helping you find the absolute best products for your skin, using research-based criteria to review beauty products from an honest, balanced perspective. Each member of the team was personally trained by Paula herself.

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