Replenix Infusion Eye Repair Serum
0.5 fl. oz. for $70
Last Updated:12.10.2012
Jar Packaging:No
Tested on animals:Yes
Review Overview

This eye-area serum is sold as "a complete eye treatment," which makes us wonder what the other Replenix eye-area products are for if this one is complete (Are the others incomplete?). As it turns out, this isn't the all-in-one solution for dark circles, puffiness, and wrinkles—not to mention you don't need a special serum for the eye area (see More Info to find out why). Still, this is intriguing enough to warrant further discussion.

First, regardless of claims, dark circles are extremely difficult to treat via skin-care products. Even in-office laser procedures are of marginal benefit. If the dark circles are caused or made worse by excess melanin (skin pigment) production, then you can absolutely lighten them with products that reduce pigment (for example, those that contain hydroquinone or niacinamide) and daily use of sunscreen (which this product doesn't contain). However, many cases of dark circles are hereditary and unrelated to melanin, so skin-lightening products are of minimal benefit. Think of all the products out there claiming to get rid of dark circles, and yet dark circles remain one of the top eye-area issues, and they aren't going away easily.

As for puffiness, topical anti-inflammatory or constricting ingredients can help reduce puffiness from fluid retention or simple swelling, but not puffiness from the undereye "bags" that occur with age as the fat pads beneath the eyes slip out of place. Unfortunately, this type of puffiness requires surgical intervention of some kind, not skin care.

On the upside, this serum contains many antioxidants and anti-inflammatory ingredients, and simply supplying the skin with these ingredients (plus daily sun protection) can go a long way toward improving the eye-area skin, or skin anywhere on the face, neck, or chest—there is nothing in here special for the eye area. This formula definitely has what it takes to improve skin in the eye area, even though a facial moisturizer or serum with similar ingredients would work just as well. The best ingredients in this eye serum can be considered anti-aging.

This serum contains two intriguing ingredients worth explaining: pinanediol and camphanediol. These naturally derived ingredients stimulate nitric oxide production in the skin, and research has shown that doing so increases microcirculation as well as skin temperature. According to one study, these ingredients helped reduce dark circles, although only 7 of 27 subjects reported this benefit, which statistically isn't all that impressive. In contrast, other research has shown that pinanediol stimulates melanin production, a process that can make dark circles worse (Sources: Nitric Oxide, August 2006, pages 70–76; and Pigment Cell Research, February 1999, pages 36–47). Ultimately, these ingredients are a bit of a gamble in terms of efficacy, but some may find that they do improve dark circles, and this product contains a potentially effective amounts of both.

This eye serum is fragrance-free and contains titanium dioxide for a cosmetic brightening effect, but not enough to provide sun protection. Although this can make dark circles less apparent, a good concealer does a much better job!

  • Fragrance-free.
  • Contains an intriguing mix of antioxidant and anti-inflammatory ingredients.
  • Skin-repairing ingredients help smooth and strengthen.
  • Expensive.
  • None of the ingredients are slam-dunks for lightening dark circles or reducing age-related puffiness.
More Info:

We know it's hard to believe, but the truth is you don't need a special product for the eye area, whether labeled eye serum or something else. Although there is much you can do to improve the skin around your eyes, the ingredients capable of doing that don't need to come from, and often aren't even included in, an eye serum. For example, most eye serums (such as this one) don't contain sunscreen, and that is a serious problem because it leaves the skin around your eyes vulnerable to sun damage, which will make dark circles and wrinkling worse!

You can save money and take superior care of your eye area by using your face product, if it is well formulated and appropriate for the skin type around your eyes!


Replenix Infusion Eye Repair Serum offers a complete eye treatment product with the benefits of peptides, and antioxidant for the treatment of dark circles, puffiness and the signs of aging.


Purified Water, Glycerin, Cucumis Sativus (Cucumber) Fruit Extract, Camellia Sinensis (Green Tea) Polyphenols, Hesperidin Methyl Chalcone, Sodium Hyaluronate, Pinanediol, Camphanediol, Dipeptide-2, N-Hydroxysuccinimide, Chrysin, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Phytonadione (Vitamin K), Macrocytis Pyrifera (Kelp) Extract, Silybum Marianum Fruit Extract, Sodium PCA, Hydrolyzed Wheat Protein, Phyllanthus Emblica Fruit Extract, Glycereth-26, Steareth-20, PVP, Triethanolamine, Xanthan Gum, Caprylyl Glycol, Phenoxyethanol, Sorbic Acid, Potassium Hydroxide, Disodium EDTA, Titanium Dioxide

Brand Overview

Topix At-A-Glance

Strengths: Most of the products are fragrance-free; packaging keeps light- and air-sensitive ingredients stable during use; several good products with retinol in varying strengths; good moisturizers and cleansers; very good body lotions.

Weaknesses: Expensive; the physician allure may seem enticing, but these products do not require a doctor's visit or medical supervision; no AHA or BHA exfoliants; no viable skin-lightening options; fragrant toner; the growth factors in the Citrix serums are potentially risky ingredients.

Topix is best known for its two chief skin-care brands, Replenix and Citrix. Of the two, we're asked most often about the Replenix collection; the Citrix line is smaller and focused on anti-aging products with vitamin C. The Replenix products contain a broader range of anti-aging ingredients, such as retinol, green tea, and grape-derived resveratrol, and the claims are broader, too—so little surprise that the Replenix products appeal to more people concerned with signs of aging. Both Replenix and Citrix offer fragrance-free formulas, albeit at fairly high prices, which is typical of most physician-dispensed lines.

A chief selling point of Topix is its physician-dispensed angle, which gives the products a medical élan; in truth, however, not a single ingredient in these products is "medicinal," prescription, or exclusive to physician-sold products. That is, you don't need to see a doctor to be "prescribed" Topix products; rather, they can be obtained from several websites, no appointment necessary. The big question is whether or not you should add any Topix products to your shopping cart—and the answer is "it depends."

Within the Replenix line, the most interesting products include the serums and moisturizers. Although none of them are superior to the best options available, most of them do offer good (though pricey) formulas that treat skin to a range of beneficial ingredients.

If you're keen on retinol (and it's a great anti-aging ingredient), Replenix has you covered with several serums offering different strengths of retinol. The various strengths allow you to "step up" to stronger retinol products once your skin has acclimated to the lower strengths. Although that sounds intriguing, it's not really necessary. As we explain in the reviews, more retinol is not necessarily better, and some may find the higher-strength retinol products too sensitizing, so caution is warranted. Indeed, some people cannot tolerate any amount of retinol!

The Citrix products aren't all that exciting unless you want vitamin C in every product. Although there's nothing wrong with vitamin C, it's a mistaken notion to focus on one hero ingredient because skin requires a variety of beneficial ingredients to look and act younger. Topix also adds growth factors to their Citrix serums, but these growth-factor ingredients are unproven for topical use and may present risks (we explain why in the reviews). In short, Citrix isn't all that exciting, and several of these products fall short in one way or another.

Our research revealed that Topix has some intriguing products, but, with few exceptions, there is nothing that you cannot find elsewhere for less money. It's important to let go of the notion that skin-care products sold at a doctor's office are superior to those sold elsewhere. The truth is: There are good and bad products in every retail outlet—knowing what you're buying is more important than where you're buying it or who's selling it!

For more information about Topix, call (800) 445-2595 or visit www.topixpharm.com.

About the Experts

The new Beautypedia Team proudly and unequivocally maintains the commitment to help you find the best products possible for your skin. We do this by relentlessly pursuing and relying on published scientific research so you will have unbiased information on what works and what doesn't-and the sneaky ways you could be making your skin worse, not better!

The Beautypedia Team reviews all products using the same research, criteria, and objectivity, whether the product being reviewed is from Paula's Choice or another brand.

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