Replenix Power of Three Cream
1 fl. oz. for $70
Category:Skin Care > Moisturizers (Daytime and Nighttime) > Moisturizer without Sunscreen
Last Updated:11.26.2014
Jar Packaging:No
Tested on animals:Yes
Review Overview

The "Power of Three" in this moisturizer's name refers to the ingredients resveratrol, caffeine, and polyphenol antioxidant from green tea. Although all of these are good anti-aging ingredients for skin, they're no more powerful or better than lots of others. And what about the Replenix CF products from Topix, which contain green tea polyphenols and caffeine, but not resveratrol? Are they less effective because they don't have the "Power of Three"? We admit, "Power of Three" is a great name, but it doesn't really help you make an informed decision—that's where we can help!

Although this product's name is not all that helpful, it's still a very good moisturizer for dry, sensitive skin. The fragrance-free formula is suitable for rosacea-prone skin, too. The cell-communicating ingredient lecithin is joined by several antioxidants, and the opaque pump-bottle packaging ensures these light- and air-sensitive ingredients stay protected so your skin can enjoy their maximum benefits.

The only drawback for some might be the price; but for what you're paying, you are getting a great moisturizer!

  • Fragrance-free; suitable for sensitive or rosacea-affected skin.
  • Emollient formula benefits dry skin.
  • Packaged to keep the light- and air-sensitive ingredients stable during use.
  • Expensive.

Replenix Power of Three Cream is an emollient formula with a soy phospholipid and hyaluronic acid base, ideal for those with dry skin. Contains green tea and caffeine.


Purified Water, Squalane, Cyclomethicone, Glyceryl Stearate, Behenyl Alcohol, Caffeine U.S.P., Palmitic Acid, Stearic Acid, Lecithin, Lauryl Alcohol, Myristyl Alcohol, Cetyl Alcohol, Dimethicone, Camellia Sinensis (Green Tea) Polyphenols, Resveratrol, Cucumis Sativus (Cucumber) Fruit Extract, Bisabolol, Chamomilla Recutita (Matricaria) Flower Extract, Glycine Soja (Soybean) Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Polysorbate-20, Carbomer, Caprylyl Glycol, Triethanolamine, Sorbic Acid, Phenoxyethanol, Tetrasodium EDTA.

Brand Overview

Topix At-A-Glance

Strengths: Most of the products are fragrance-free; packaging keeps light- and air-sensitive ingredients stable during use; several good products with retinol in varying strengths; good moisturizers and cleansers; very good body lotions.

Weaknesses: Expensive; the physician allure may seem enticing, but these products do not require a doctor's visit or medical supervision; no AHA or BHA exfoliants; no viable skin-lightening options; fragrant toner; the growth factors in the Citrix serums are potentially risky ingredients.

Topix is best known for its two chief skin-care brands, Replenix and Citrix. Of the two, we're asked most often about the Replenix collection; the Citrix line is smaller and focused on anti-aging products with vitamin C. The Replenix products contain a broader range of anti-aging ingredients, such as retinol, green tea, and grape-derived resveratrol, and the claims are broader, too—so little surprise that the Replenix products appeal to more people concerned with signs of aging. Both Replenix and Citrix offer fragrance-free formulas, albeit at fairly high prices, which is typical of most physician-dispensed lines.

A chief selling point of Topix is its physician-dispensed angle, which gives the products a medical élan; in truth, however, not a single ingredient in these products is "medicinal," prescription, or exclusive to physician-sold products. That is, you don't need to see a doctor to be "prescribed" Topix products; rather, they can be obtained from several websites, no appointment necessary. The big question is whether or not you should add any Topix products to your shopping cart—and the answer is "it depends."

Within the Replenix line, the most interesting products include the serums and moisturizers. Although none of them are superior to the best options available, most of them do offer good (though pricey) formulas that treat skin to a range of beneficial ingredients.

If you're keen on retinol (and it's a great anti-aging ingredient), Replenix has you covered with several serums offering different strengths of retinol. The various strengths allow you to "step up" to stronger retinol products once your skin has acclimated to the lower strengths. Although that sounds intriguing, it's not really necessary. As we explain in the reviews, more retinol is not necessarily better, and some may find the higher-strength retinol products too sensitizing, so caution is warranted. Indeed, some people cannot tolerate any amount of retinol!

The Citrix products aren't all that exciting unless you want vitamin C in every product. Although there's nothing wrong with vitamin C, it's a mistaken notion to focus on one hero ingredient because skin requires a variety of beneficial ingredients to look and act younger. Topix also adds growth factors to their Citrix serums, but these growth-factor ingredients are unproven for topical use and may present risks (we explain why in the reviews). In short, Citrix isn't all that exciting, and several of these products fall short in one way or another.

Our research revealed that Topix has some intriguing products, but, with few exceptions, there is nothing that you cannot find elsewhere for less money. It's important to let go of the notion that skin-care products sold at a doctor's office are superior to those sold elsewhere. The truth is: There are good and bad products in every retail outlet—knowing what you're buying is more important than where you're buying it or who's selling it!

For more information about Topix, call (800) 445-2595 or visit www.topixpharm.com.

About the Experts

The new Beautypedia Team proudly and unequivocally maintains the commitment to help you find the best products possible for your skin. We do this by relentlessly pursuing and relying on published scientific research so you will have unbiased information on what works and what doesn't-and the sneaky ways you could be making your skin worse, not better!

The Beautypedia Team reviews all products using the same research, criteria, and objectivity, whether the product being reviewed is from Paula's Choice or another brand.

Member Comments
Summary of Member Comments
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Can someone please tell me if it is a lotion or a cream consistency? Thank you

Reviewed by
Beautypedia Team Response

Hi there!  It has a creamier texture.

Excellent combined with Resist Line

Truly gentle for sensitive skin. Using two months with my paulas choice resist line. Marvelous to use together. Skin is radiant and healthy. This is so gentle yet truly hydrating when I don't have time for all my PC regimen.

Reviewed by
Kimberly T.
So far so good!

I am always on the look for something to soothe and nourish my skin. I am a frequent user of Tazorac and Paula's retinol serum. This is very nice. I got it 25% off so it wasn't that bad on price. I like the twist pump container. It really protects the product. I have also been intrigued by reservatrol so thought I'd give this a try. Thanks for the review Paula. You always help me to make educated decisions :)

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