Replenix Restorative Nighttime Bio-Therapy
2 fl. oz. for $66
Last Updated:03.16.2015
Jar Packaging:Yes
Tested on animals:Yes
Review Overview

This moisturizer contains some excellent ingredients to help repair skin's barrier without feeling thick or heavy, making it well-suited for those with combination to oily skin.

Don't let the packaging deceive you: This is housed in an airless jar, which works beautifully to keep the light- and air-sensitive ingredients this contains stable with each use.

Replenix Restorative Nighttime Bio-Therapy missed our top rating due to the inclusion of fragrance. Although it's the last ingredient listed, we were disappointed to find the citrus-like scent lingers long after application, meaning it poses a risk of irritation even in this small amount. If you decide to try this, pay close attention to how your skin responds and think twice before applying this around your eyes.

  • Lightweight, silky texture glides over skin.
  • Airless jar packaging keeps sensitive ingredients stable during use.
  • Formula is rich in antioxidants and vital skin-repairing ingredients.
  • Strong, lingering citrus fragrance may pose a risk of irritation.

This sophisticated, moisture-boosting, decadently rich night cream nourishes dry skin back to optimum health. Combats skin dryness and enhances barrier function overnight with a controlled and powerful delivery system that is designed to attract, hold and distribute moisture.


Purified Water, Cyclopentasiloxane, Sodium PCA, Glycerin, Caprylic/Triglyceride, Polysorbate-60, Cetearyl Alcohol, Yucca Glauca Root Extract, Dimethicone, Cetearyl Glucoside, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Ceramide NP, Ceramide AP, Ceramide EOP, Sodium Hyaluronate, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Camellia Sinensis (Green Tea) Polyphenols, Malus Domestica Fruit Cell Culture Extract, Squalane, Ceramide 2, Tetrapeptide-21, Resveratrol, Bisabolol, Caffeine, Lecithin, Glyceryl Stearate, PEG-100 Stearate, Dimethicone Crosspolymer, Carbomer, Xanthan Gum, Phenoxyethanol. Sorbic Acid, Caprylyl Glycol, Disodium EDTA, Fragrance.

Brand Overview

Topix At-A-Glance

Strengths: Most of the products are fragrance-free; packaging keeps light- and air-sensitive ingredients stable during use; several good products with retinol in varying strengths; good moisturizers and cleansers; very good body lotions.

Weaknesses: Expensive; the physician allure may seem enticing, but these products do not require a doctor's visit or medical supervision; no AHA or BHA exfoliants; no viable skin-lightening options; fragrant toner; the growth factors in the Citrix serums are potentially risky ingredients.

Topix is best known for its two chief skin-care brands, Replenix and Citrix. Of the two, we're asked most often about the Replenix collection; the Citrix line is smaller and focused on anti-aging products with vitamin C. The Replenix products contain a broader range of anti-aging ingredients, such as retinol, green tea, and grape-derived resveratrol, and the claims are broader, too—so little surprise that the Replenix products appeal to more people concerned with signs of aging. Both Replenix and Citrix offer fragrance-free formulas, albeit at fairly high prices, which is typical of most physician-dispensed lines.

A chief selling point of Topix is its physician-dispensed angle, which gives the products a medical élan; in truth, however, not a single ingredient in these products is "medicinal," prescription, or exclusive to physician-sold products. That is, you don't need to see a doctor to be "prescribed" Topix products; rather, they can be obtained from several websites, no appointment necessary. The big question is whether or not you should add any Topix products to your shopping cart—and the answer is "it depends."

Within the Replenix line, the most interesting products include the serums and moisturizers. Although none of them are superior to the best options available, most of them do offer good (though pricey) formulas that treat skin to a range of beneficial ingredients.

If you're keen on retinol (and it's a great anti-aging ingredient), Replenix has you covered with several serums offering different strengths of retinol. The various strengths allow you to "step up" to stronger retinol products once your skin has acclimated to the lower strengths. Although that sounds intriguing, it's not really necessary. As we explain in the reviews, more retinol is not necessarily better, and some may find the higher-strength retinol products too sensitizing, so caution is warranted. Indeed, some people cannot tolerate any amount of retinol!

The Citrix products aren't all that exciting unless you want vitamin C in every product. Although there's nothing wrong with vitamin C, it's a mistaken notion to focus on one hero ingredient because skin requires a variety of beneficial ingredients to look and act younger. Topix also adds growth factors to their Citrix serums, but these growth-factor ingredients are unproven for topical use and may present risks (we explain why in the reviews). In short, Citrix isn't all that exciting, and several of these products fall short in one way or another.

Our research revealed that Topix has some intriguing products, but, with few exceptions, there is nothing that you cannot find elsewhere for less money. It's important to let go of the notion that skin-care products sold at a doctor's office are superior to those sold elsewhere. The truth is: There are good and bad products in every retail outlet—knowing what you're buying is more important than where you're buying it or who's selling it!

For more information about Topix, call (800) 445-2595 or visit www.topixpharm.com.

About the Experts

The new Beautypedia Team proudly and unequivocally maintains the commitment to help you find the best products possible for your skin. We do this by relentlessly pursuing and relying on published scientific research so you will have unbiased information on what works and what doesn't-and the sneaky ways you could be making your skin worse, not better!

The Beautypedia Team reviews all products using the same research, criteria, and objectivity, whether the product being reviewed is from Paula's Choice or another brand.

Member Comments
Summary of Member Comments
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Good moisture for those on rx retinoids!

Love applying this cream after Tazorac cream at night. It keeps my dry, winter skin very soft and deeply moisturized. In addition, it prevents skin redness and irritation associated with dry skin on retinoids and other prescriptions. My dermatologist loves it,recommends it, and says the fragrance will not irritate unless skin has an immediate reaction to it (which most skin will not). Also, price per ounce is very reasonable considering it contains green tea polyphenols, stem cells,and peptides.

Reviewed by
Fragrance- what a shame.

I would love to try this product, because it sounds like a good moisturizer. But, the company ruined it by including fragrance! What is going on with these companies that put fragrance in a facial moisturizer?? Especially a line like this, which is supposedly dispensed by doctors. Fragrance is an irritant. I agree with the PC reviews regarding the inclusion of fragrance in facial products- it shouldn't be there. Personally, I always say, "Fragrance belongs in perfume, not on your face"!

Reviewed by
superior hydration

Offers superior hydration in an elegant, fast absorbing cream. Additionally it has a peptide and stem cell for anti-aging benefits as well as antioxidants to protect the cells and new collagen. Love the pump jar that protects the cream from oxidation. Also quite reparative with the bio-mimetic cerimides. FYI, this company does not test on animals as stated in the overview. For $66 this night cream packs a big punch!

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