A plant that can be very irritating to the skin and can trigger allergic reactions when a constituent (more technically, a sesquiterpene lactone) of the feverfew plant known as parthenolide is present. If the parthenolide is removed from feverfew, the ingredient is not a problem for skin and may actually be beneficial. That’s because parthenolide-free feverfew has potent anti-inflammatory properties and may reduce redness in skin.
Interestingly, when parthenolide is present and feverfew is taken orally it has been shown to relieve migraines and have anti-inflammatory properties, including those related to pain reduction for certain types of arthritis (Sources: Inflammopharmacology, February 2009, pages 42-49; Evidence-Based Complementary and Alternative Medicine, March 2009, pages 91-98; Journal of Drugs in Dermatology, July 2008, pages s7-s-12; Dermatitis, December 2007, pages 225-229; and Contact Dermatitis, October 2001, pages 197–204). When it comes to skincare products containing feverfew, you need to contact the company to confirm the feverfew in their products is parthenolide-free. If they don’t know or won’t tell you, do not use the product (this is especially true if you have plant allergies).