Considered the most effective over-the-counter choice for a topical antibacterial agent in the treatment of acne. 
The amount of research demonstrating the effectiveness of benzoyl peroxide is exhaustive and conclusive. [1,2,3] Among benzoyl peroxide’s attributes is its ability to penetrate into the hair follicle to reach the bacteria that cause the problem, and then kill them—with a low risk of sensitivity. It also doesn’t pose the problem of bacterial resistance that some prescription topical antibacterials (antibiotics) do. 
Benzoyl peroxide solutions range in strength from 2.5% to 10%. It is best to start with lower concentrations because a 2.5% benzoyl peroxide product is much less irritating than a 5% or 10% concentration, and it can be just as effective. [1,2,3]
- Bowe W, Shalita A. Effective Over-the-Counter Acne Treatments. Semin Cutan Med Surg. 2008;27(3):170-176.
- Sagransky M, Yentzer B, Feldman S. Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. Expert Opin Pharmacother. 2009;10(15):2555-62.
- Simonart T. Newer approaches to the treatment of acne vulgaris. Am J Clin Dermatol.. 2012;13(6):357-64.
- Bowe W. Antibiotic Resistance and Acne: Where We Stand and What the Future Holds. J Drugs Dermatol.. 2014;13(6):S66-S70.