Cell-Communicating Ingredients
Compound formed by the metabolism of the amino acid creatine. Creatine resides primarily in muscle tissue and blood and is normally excreted in the urine as creatinine. Both creatine and creatinine are cell-signaling ingredients in the body. Theoretically, they should perform a similar function when applied topically, but there is no research to support this. Research on oral supplementation with creatinine has had mixed or unimpressive results, particularly for those who take it to build lean muscle mass (Source:

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Paula Begoun is the best-selling author of 20 books on skin care and makeup. She is known worldwide as the Cosmetics Cop and creator of Paula's Choice. Paula's expertise has led to hundreds of appearances on national and international television including:

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The Paula's Choice Research Team is dedicated to helping you find the absolute best products for your skin, using research-based criteria to review beauty products from an honest, balanced perspective. Each member of the team was personally trained by Paula herself.

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