Cell-Communicating Ingredients
An acronym for Silent Information Regulator Two proteins. They are a class of proteins thought to influence aging and regulation of the life and death cycle of cells. Sirtuins act as cellular energy sensors that regulate numerous other proteins involved in energy and glucose balance, which in turn induce a wide range of physiological changes that counteract detrimental effects of metabolic stressors. Some cosmetic companies are claiming they contain ingredients that can stimulate sirtuins in skin to prevent and reduce wrinkles. The major ingredient known to affect sirtuins is resveratrol. However those studies have been about oral consumption and not topical application. The research about its effect on skin has been done by the cosmetic companies themselves. (Source: Current Opinion in Clinical Nutrition and Metabolic Care, July 2009, pages 431-437 and Journal of Cosmetic Dermatology, March 2008, pages 2-7).

«Back to Ingredient Dictionary

About the Experts

Paula Begoun is the best-selling author of 20 books on skin care and makeup. She is known worldwide as the Cosmetics Cop and creator of Paula's Choice. Paula's expertise has led to hundreds of appearances on national and international television including:

View Media Highlights

The Paula's Choice Research Team is dedicated to helping you sort through the myths and half-truths of the cosmetic industry. With their expert advice, you’ll have the facts you need to take the best possible care of your skin.

PCWEB-WWW1 v1.0.0.431 10/4/2015 10:35:45 AM
Skip to Top of Page

Free Email Sign-Up

- (Less Frequent)
- Expert Advice Newsletter (twice a month)
- New reviews on Beautypedia (twice a month)

Birthday (Optional)



Paula’s Choice Auto Delivery is a quick and convenient way to make sure you never run out of your favorite products again. Just select the products you can’t live without, choose how often you’d like them delivered and we’ll take care of the rest.

20% Off One Item + Free Shipping on $50+