Contains chemical constituents such as proanthocyanidins, polyphenols, flavonoids, and anthocyanins, all of which are very potent antioxidants that help to diminish the sun’s damaging effects and reduce free-radical damage. [1,2] Grape extract has also been shown to have wound-healing properties. [3,4] When combined with other antioxidants, topical application reduces the biomarkers in skin responsible for skin cancer.  Red grapes contain resveratrol, considered a very potent antioxidant and believed to be chiefly responsible for the health benefits of red wine (and grape juice). 
- Shi J, Yu J, Pohorly J, Kakuda Y. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food. 2003;6(4):291-9.
- Leifert W, Abeywardena M. Cardioprotective actions of grape polyphenols. Nutr Res. 2008;28(11):729-37.
- Khanna S, Venojarvi M, Roy S, Sharma N, Trikha P, Bagchi D, Bagchi M, Sen C. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med. 2002;33(8):1089-96.
- Hemmati A, Aghel N, Rashidi I, Gholampur-Aghdami A. Topical grape (Vitis vinifera) seed extract promotes repair of full thickness wound in rabbit. Int Wound J. 2011;8(5):514-20.
- Yuan X, Liu W, Hao J, Gu W, Zhao Y. Topical grape seed proanthocyandin extract reduces sunburn cells and mutant p53 positive epidermal cell formation, and prevents depletion of Langerhans cells in an acute sunburn model. Photomed Laser Surg. 2012;30(1):20-5.
- Kaur M, Agarwal C, Agarwal R. Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. J Nutr. 2009;139(9):1806S-12S.