Also known as MSM. There is no published research to back up claims made about any benefit this sulfur compound may have for arthritis or other physical ailments. There is no research about its effect when applied topically. Sulfur is stored in every cell of the body, particularly in the hair, nails, and connective tissue of joints and skin, where it is an important structural protein component. An MSM manufacturer sponsored two very small trials, but the results have not been published. Until additional research is published, MSM enthusiasm should be tempered. MSM is available in capsules and powder for oral intake or in creams for topical use. To date, there have been no reports of toxicity (Sources: Harvard Health Letter, August 2000, www.health.harvard.edu; Healthnotes Review of Complementary and Integrative Medicine, www.healthwell.com/healthnotes/herb; and www.drweil.com).