Low-dosage birth-control pills (generic norgestimate/ethinyl estradiol) approved for use in the United States for the treatment of acne. In Canada, the birth control pill Diane-35, a combination of cyproterone acetate and ethinyl estradiol, is approved for treatment of acne (Source: Skin Therapy Letter, 1999, volume 4, number 4, www.dermatology.org/skintherapy). According to a double-blind, placebo-controlled study published in Fertility and Sterility (September 2001, pages 461–468), other “low-dose birth-control pills can be an effective and safe treatment for moderate acne.” The double-blind, placebo-controlled, randomized clinical trial found that the birth-control pill containing levonorgestrel (Alesse) reduced the appearance of acne.