Hydroquinone derivative isolated from the leaves of the bearberry shrub, cranberry, blueberry, some mushrooms, and most types of pears. Arbutin’s hydroquinone content gives it melanin-inhibiting properties.
Arbutin has an increasing amount of research attesting to its effectiveness for inhibiting melanin production when applied to skin cells or in animal test models.[1, 2]
In terms of concentration protocols, limited but compelling research has demonstrated that a 1% concentration is necessary.
- Migas P, Krauze-Baranowska M. The significance of arbutin and its derivatives in therapy and cosmetics. Phytochem Let. 2015;13:35-40.
- Sugimoto K, Nishimura T, Nomura K, Sugimoto K, T. K. Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanom a cells and a three-dimensional human skin model.. Biol Pharm Bull. 2004;27(4):510-4.
- Shin J, Park K. Current clinical use of depigmenting agents. Dermatologica sinica. 2014;205: e207.