Potent polyphenolic antioxidant that is abundant in red grapes and, therefore, in red wine (unfortunately for some of us, not in white wine). Resveratrol has been reported in numerous studies to be one of the most potent natural chemopreventive agents inhibiting the cellular processes associated with tumor development, including initiation, promotion, and progression. It also has significant anti-inflammatory properties. Conversely, there is research showing it to be associated with cell death when applied topically if skin is exposed to sunlight. Of course, if you are applying a well formulated sunscreen rated SPF 15 or greater daily, this risk is negated (Sources: Anticancer Research, September–October 2004, pages 2783–2840; Medicinal Chemistry, November 2005, pages 629–633; Molecular Nutrition and Food Research, May 2005, pages 405–430; Antioxidant Redox Signal, December 2001, pages 1041–1064; and Mutation Research, Genetic Toxicology and Environmental Mutagenesis, September 2001, pages 171–180).