Potent polyphenolic antioxidant abundant in red grapes and, therefore, in red wine. Resveratrol has been reported in numerous studies to be one of the most potent natural chemopreventive agents for inhibiting the cellular processes associated with tumor development, including initiation, promotion, and progression. It also has significant anti-inflammatory properties and seems to have a stimulating and protective effect on glutathione, the body’s master antioxidant. [1,2,3,4] Conversely, there’s also research showing it to be associated with cell death when applied in pure doses directly to skin cells that are then exposed to UV radiation. Of course, this has nothing to do with how resveratrol is used in skincare products, but it’s an interesting example of how more is not necessarily better when it comes to skincare ingredients!
- Soeur J, Eilstein J, Léreaux G, Jones C, Marrot L. Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesis. Free Radic Biol Med. 2015;78:213-23.
- Aggarwal B, Bhardwaj A, Aggarwal R, Seeram N, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004;24(5A):2783-840.
- de la Lastra C, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005;49(5):405-30.
- Bhat K, Kosmeder 2nd J, Pezzuto J. Biological effects of resveratrol. Antioxid Redox Signal. 2001;3(6):1041-64.