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Resist Intensive Wrinkle-Repair Retinol Serum

This silky serum blends retinol and antioxidants to help provide firmer-looking skin, smooth wrinkles and soften fine lines so skin of any age looks younger.
Item #: 771
  • Anti-Aging, Wrinkles
  • For All Skin Types
  • Stabilized retinol reduces the appearance of wrinkles
  • Vitamin C brightens skin, helps fade the appearance of brown spots & evens skin tone
  • Kelp extract & oat kernel oil soothe & minimize redness
  • Luxuriously silky texture absorbs easily, leaving skin soft & smooth

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What makes this product unique?
Paula's Choice Resist Intensive Wrinkle-Repair Retinol Serum is an exclusive formula that utilizes a proprietary blend of highly stabilized retinol, potent antioxidants, and anti-aging ingredients. Its soothing, silky texture goes to work immediately to help skin of any age look younger. Anti-irritants reduce redness and soothe sensitive skin. With ongoing use, you will see smoother skin, with an improved appearance of wrinkles and skin tone.

This product is 100% fragrance- and colorant-free.

Who is this product for?
Anyone concerned with improving the appearance of aging skin and helping sun-damaged skin look younger and healthier. Ideal for use with Paula's Choice Resist line of anti-aging products. May be alternated with our best-selling Resist Super Antioxidant Concentrate Serum.

Sources to support the claims made for Resist Intensive Wrinkle-Repair Retinol Serum

Duodecim, Volume 128, Issue 22, 2012, pages 2,327–2,335; Journal of the European Academy of Dermatology and Venereology, September 2011, ePublication; Experimental Dermatology, July 2011, pages 572–576; Journal of Drugs in Dermatology, June 2011, pages 614–620; Fitoterapia, March 2011, pages 208–211; Lipids, September 2010, pages 833–841; Oxidative Medicine and Cellular Longevity, January-February 2010, pages 35–43; The Journal of Dermatological Treatment, May 2009, pages 276–281; Journal of the Indian Medical Association, April 2009, pages 219–222; American Journal of Clinical Dermatology, June 2008, pages 369–381; International Journal of Cosmetic Science, June 2008, pages 175–182; Journal of Dermatological Science, May 2008, pages 99–107; Archives of Dermatology, May 2007, pages 606–612; and Clinical Interventions in Aging, April 2006, pages 327-348.

Key Ingredients: retinol, caprylic/capric triglyceride, squalane, licorice extract, cell-communicating ingredients, Avena sativa, Laminaria ochroleuca extract, bisabolol, lecithin, palm oil, vitamin C, anti-irritant, antioxidant, vitamin E, kelp extract

Product Ingredients:

Cyclopentasiloxane, Dimethiconol (silicone slip agents/suspending agents), Neopentyl Glycol Diheptanoate (skin-conditioning agent), Dicaprylyl Carbonate (emollient), Caprylic/Capric Triglyceride (skin-repairing ingredient), Phenyl Trimethicone (silicone slip agent), Squalane (emollient), Bisabolol (anti-irritant), Tetrahexyldecyl Ascorbate (stabilized vitamin C/antioxidant), Retinol (cell-communicating ingredient/antioxidant), Tocotrienols (vitamin E-based antioxidant), Tocopherol (vitamin E/antioxidant), Lecithin (cell-communicating ingredient), Laminaria Ochroleuca (Kelp) Extract (anti-irritant), Avena Sativa (Oat) Kernel Oil (anti-irritant), Elaeis Guineensis (Palm) Oil (skin-repairing ingredient), Stearyl Glycyrrhetinate (licorice-derived anti-irritant), Hexylene Glycol (slip agent), Caprylyl Glycol (emollient), Ethylhexylglycerin (skin-conditioning agent), Phenoxyethanol (preservative).

DIRECTIONS: Apply after cleansing, toning and exfoliating. Smooth a few drops onto face, neck and eye area before moisturizing. For daytime, follow with a broad-spectrum sunscreen rated SPF 25 or greater. May be alternated with a Paula’s Choice serum that does not contain retinol.

Detailed instructions on how/when to apply your Paula's Choice products can be found in our How to Put Together Your Own Skincare Routine article.

How does Resist Intensive Wrinkle-Repair Retinol Serum differ from the other Antioxidant Concentrates that Paula's Choice offers?

The most notable difference is that Resist Intensive Wrinkle-Repair Retinol Serum contains a higher amount of retinol than our Skin Recovery and Skin Balancing serums with retinol. The Resist Super Antioxidant Concentrate Serum does not contain retinol and as such is an excellent serum to alternate with the Intensive Wrinkle-Repair Retinol Serum. Both of the Resist serums were designed for all skin types, whereas Skin Recovery Super Antioxidant Concentrate Serum is best for normal to very dry skin and Skin Balancing Super Antioxidant Mattifying Concentrate is best for normal to oily or combination skin.

Every Paula's Choice Super Antioxidant Concentrate Serum is silicone-based and contains an effective blend of antioxidants, skin-repairing ingredients, and cell-communicating ingredients to restore skin and significantly reduce wrinkles, increase collagen production, and improve skin color.

Which Paula's Choice serum should I use?

All skin types can use any of our serums, but there are some formulary distinctions that make certain Paula's Choice serums preferred for specific skin types. Here's how they break down:

  • Resist Super Antioxidant Concentrate Serum and Resist Intensive Wrinkle Repair Retinol Serum can be used by all skin types, including sensitive skin.
  • Skin Recovery Super Antioxidant Concentrate Serum is best for normal to very dry skin because it contains plant oils.
  • Skin Balancing Super Antioxidant Concentrate is best for normal to oily or combination skin because it has the lightest texture and weightless finish.
  • Resist Super Antioxidant Concentrate Serum is one of two Paula’s Choice serums that does not contain retinol. It’s the natural choice for anyone whose skin cannot tolerate retinol.
  • Resist Ultra-Light Super Antioxidant Concentrate Serum has the lightest texture of all the Resist serums and is our only water-based (rather than silicone-based) serum. It does not contain retinol, so is recommended for those whose skin cannot tolerate this ingredient (or it may be used with one of our retinol serums).

Is Resist Intensive Wrinkle-Repair Retinol Serum better than the other Paula's Choice serums?

Not better, just different. Think of it like broccoli and carrots: both are good for you but provide different nutritional benefits your body needs to be healthy. Resist Intensive Wrinkle-Repair Retinol Serum was formulated with a greater amount of retinol to provide a higher degree of wrinkle repair—but all Paula's Choice serums contain an array of ingredients proven to help repair wrinkles and other signs of aging.

Can I use two Paula's Choice products with retinol, such as Resist Barrier Repair Moisturizer with Resist Intensive Wrinkle-Repair Retinol Serum?

Yes, this is fine; however, if you noticed that applying such products at the same time causes signs of irritation (such as redness or flaking) it would be best to apply one in the morning and the other at night, or consider switching to Resist Super Antioxidant Concentrate Serum, which is retinol-free.

Can I use Resist Intensive Wrinkle-Repair Retinol Serum with my prescription retinoid product (examples: Renova, Retin-A, generic tretinoin).

Yes, but generally speaking, you don't necessarily need to use retinol and a prescription retinoid. Many will do fine with one or the other, or you can apply the prescription retinoid at night and apply the retinol product during the day, always being sure to protect your skin with a product rated SPF 15 or greater. Keep in mind that using multiple retinoid products increases the risk of irritation, which is never the goal. With retinoids, more is not automatically better!

Can I apply Resist Intensive Wrinkle-Repair Retinol Serum with a product medicated with benzoyl peroxide?

Yes. For best results, apply the benzoyl peroxide product to breakout-prone areas, allow to dry, then follow with Resist Intensive Wrinkle-Repair Retinol Serum. Note that benzoyl peroxide should not be applied at the same time as the prescription retinoid tretinoin, as it renders this active ingredient ineffective. It does not appear to have this same effect on retinol.

What is the percentage of retinol in Resist Intensive Wrinkle-Repair Retinol Serum?

Resist Intensive Wrinkle-Repair Retinol Serum was formulated with a potent amount of retinol to provide a higher degree of wrinkle repair—but all Paula's Choice retinol treatments contain an array of ingredients proven to help repair wrinkles and other signs of aging.

The percentage of retinol needed for efficacy is generally between 0.01% and 1%, which is quite a range, but further proof of just how powerful retinol is! For more on percentages of retinol in Paula’s Choice products, see our article Which Strength of Retinol Do I Need?

All of these products may be used with Resist Intensive Wrinkle-Repair Retinol Serum or on their own, as each treats skin to a beneficial range of anti-aging ingredients.

Can I layer Paula's Choice serums? Do I need to do this?

Yes, you can and it does not matter which serum is applied first. Experiment to see which order of serum application works best for you. Although it's fine to layer our serums, ultimately you do not need to do this because every Paula's Choice serum treats skin to an array of brilliant ingredients. Because layering two serums plus your daytime moisturizer may feel too heavy under makeup, we recommend those who wish to layer our serums do so at night.

What makes Resist Intensive Wrinkle-Repair Retinol Serum better than other retinol treatments?

Resist Intensive Wrinkle-Repair Retinol Serum holds several advantages over other serums with retinol:

  • In addition to its targeted retinol formula, this serum also treats skin to a range of antioxidants, repairing ingredients, and anti-irritants. Each of these ingredients has published research showing how they improve aging skin.
  • The amount of retinol in this serum was expertly calibrated to ensure maximum efficacy without irritation. You're getting all of the benefits of retinol without bothersome side effects such as redness or flaking.
  • The chemist Paula chose to formulate this serum is a retinol expert who made sure every element of this targeted treatment was designed to improve wrinkles and signs of aging without tipping the scale toward irritation.
  • This retinol serum is packaged to ensure the efficacy and stability of the formula. The retinol itself is carefully handled and never exposed to degrading light or oxygen at any time during manufacturing. The Resist Intensive Wrinkle-Repair Retinol Serum requires specially designed packaging to keep this amount of retinol stable (droppers, pads or tubes would compromise the retinol's effectiveness). That means the serum you receive can deliver the full, pure potency of retinol.
  • You can rely on Paula and her Product Development team to provide the most advanced formulas at reasonable prices!

At what point after my laser and/or peel procedure can I begin using my serum again?

First, we urge you to follow the post-procedure instructions your doctor or nurse provided. If nothing was mentioned about when to resume use of a serum, please contact the doctor's office where you had the procedure done. Otherwise, our general advice is to begin using your serum again as soon as possible. All of our serums contain skin-repairing, anti-inflammatory, and replenishing ingredients that calm reddened skin and help enhance the healing process. Make sure you're also protecting your "new" skin every day with a product rated SPF 15 or greater.

Is Resist Intensive Wrinkle-Repair Retinol Serum suitable for those with rosacea?

Yes. Research has shown that retinol can reduce inflammation that leads to symptoms of rosacea. The other antioxidants and soothing agents in this serum will help calm redness and soothe skin as they deliver anti-aging benefits.

I keep depressing the pump, but no product is coming out.

This product is packaged in an airless pump dispenser which utilizes a vacuum system to dispense and keep the contents fresh. Airless packaging helps to keep air and contaminates out of the product, which enhances the formula's stability and effectiveness.

When using your product for the first time, you may need to “prime” the dispenser. To prime, simply pump the dispenser slowly about 10-15 times. If the dispenser stops working at any time, simply repeat the "priming" step. Do not attempt to dismantle the package.

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