RESIST Retinol Serum

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RESIST Intensive Wrinkle-Repair Retinol Serum

For All Skin Types
Item #: 771
  • Effective for: Acne Breakouts, Anti-Aging, Brown Spots, Redness, Rosacea, Wrinkles
  • Supercharged blend of retinol and antioxidants help skin look and act younger
  • Repairs wrinkles and sun damage
  • Builds skin-firming collagen
  • Reduces dark spots
  • Anti-irritants reduce redness and soothe sensitive skin
  • Helps fade red marks from past breakouts
  • Clinically proven non-irritating
  • 100% fragrance free, no added dyes
  • No animal testing
  • View the research and studies showing the benefits of using this product here.

Can be used as an enhancement in our 5-Step RESIST Anti-Aging System

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Customer Ratings:

82 out of 100
(Based on 280 Reviews)
Page of 12 Next »
  1. Lizzy S.
    Reviewed on Friday, June 14, 2013
    100 out of 100
    • Rating
      Best / 4
    Love this!
    • I got a deluxe sample of this with a recent order I placed. I have rosacea and super sensitive skin so I was hoping this would work for me as I'm in my 30's and wanting to take good care of my skin. I loved this! It does not irritate my skin at all and I love that I can use it around my eyes with no problem. I definitely see an improvement in the tone and texture of my skin. My younger sister recently touched the skin on my cheek and was surprised at how firm my skin was compared to hers.

  2. Sun L.
    Reviewed on Monday, June 10, 2013
    100 out of 100
    • Rating
      Best / 4
    So happy I tried this!
    • My first experience with the Resist Retinol was the deluxe trial size that was sent out as a promo to all customers who spent $50 or more. I was very reluctant to try it, due to bad allergic reaction to another skincare line that also contained Retinol. Finally, I shrugged and decided to patch test the Resist Retinol. Turns out I'm not allergic to retinol, just that other skincare line! No irritation and it has completely flattened out a frown line/wrinkle that I had between my eyebrows.

  3. Jeannine P.
    Reviewed on Sunday, June 09, 2013
    100 out of 100
    • Rating
      Best / 4
    GLAD I TRIED IT
    • ONLY tried this because I received a free 2-week size. I stay away from PC serums due to their slick texture/my oily skin/pimples/blackheads. Never used retinol before; use other BHA PC products. Decided to try this-at 55 I've noticed dramatic thinning of skin, first fine lines, deepening crows feet, sun damage. After 2 mos., all were substantially diminished; skin texture evened out; thinning skin looked/felt better/acne reduced. Has NOT reduced dark spots. No unwanted side affects/irritation.

  4. Lisa K
    Reviewed on Friday, June 07, 2013
    20 out of 100
    • Rating
      Worst / 4
    Do not use if you are acne prone
    • There are many Paula's Choice products that I love but this definitely is not one of them! They may call this is serum, but it is very oily and caused me to breakout. I have always been acne prone, so when I first started using this and broke out, I stopped it for a month, just to make sure it was not a coincidence. Unfortunately the same thing happened the second time I tried it.

  5. KRISTIN d.
    Reviewed on Wednesday, June 05, 2013
    100 out of 100
    • Rating
      Best / 4
    Love this!
    • This has cleared my acne spots. When I use this I wake up with glowing skin. For some reason I still get a few zits on my right cheek and this keeps it at bay. No irritation and I love how my skin looks!

  6. Nadia D
    Reviewed on Monday, May 27, 2013
    80 out of 100
    • Rating
      Good / 4
    Great product!
    • I was lucky enough to win this months ago, and I really liked it! It really hydrated my skin, and NEVER irritated it! Paula's so awesome at creating formulas with ingredients that so often cause sensitivity for people, but don't when included in her line's formulation. It's also great because you only need a LITTLE amount for it to work, so it lasted me....no joke...six months! The reason why I'm not giving it five stars is because I actually prefer the mattifying skin balancing gel better!

  7. Candice F
    Reviewed on Friday, May 24, 2013
    80 out of 100
    • Rating
      Good / 4
    Fading my acne scars!
    • I would like to rate this excellent, but only have been using for a few weeks. I received this as a three week free sample and seems to be helping with the pigment of my acne scars. I usually have to apply heavy concealer on my chin, but lately have noticed the reddish/purple color has faded. I am definalety buying more, and recommend to anyone that suffers from acne scars as myself. Thank u Paula and company for sending me to try! Super silky feeling!

  8. Michelle G.
    Reviewed on Thursday, May 23, 2013
    100 out of 100
    • Rating
      Best / 4
    Best Serum Ever
    • I have tried many serums since I've noticed slight signs of aging and this one is so powerful. My skin is more firm, soft, and smooth. My frown line has improved and not one of the other brands helped with that. I don't need moisturizer under my eyes anymore. I just bought some bb cream from Lancôme and received a sample of visionaire and feel like throwing it away. True fan forever. Now I am curious about trying Paula's makeup.

  9. Vanessa P.
    Reviewed on Tuesday, May 21, 2013
    20 out of 100
    • Rating
      Worst / 4
    Caused Scaring Acne
    • Unfortunately for me, this product caused bad acne, some of which have left tiny scars. I bought this after a recommendation by a skin care expert; now that I'm in my late 20s my skin has become dry and acne prone. I began my new routine only to see acne all over. Thinking my skin was changing, I bought the Clear Skin lotion too. The acne only became worse. I stopped using all skin products, and my acne healed. Once I re-added this, the bad acne returned. I stopped using it, and the acne healed

    Customer Service Response
    Replied on: Tuesday, May 21, 2013
    Thank you for your review and we are sorry to hear this product didn't mesh well with your skin. While there are no commonly problematic ingredients in this formula for acne-prone skin types, sometimes a combination of unique factors or sensitivities is to blame. Please contact our Customer Care team for assistance with a credit or exchange as well as product/routine recommendations for your skin type and concerns.
    —Admin
  10. Beth K.
    Reviewed on Tuesday, May 14, 2013
    100 out of 100
    • Rating
      Best / 4
    A Great Product
    • This product really worked for me. I'm 52 and the lines around my eyes and smile area are less noticeable than before. I have a hard time finding anythiing that works on my fine lines. This worked and I recommend it.

  11. Marti P.
    Reviewed on Tuesday, May 14, 2013
    100 out of 100
    • Rating
      Best / 4
    Love it
    • Received the 3-week sample and began using it at night. My cheeks feel smoother and the blackheads on my nose seem to be "fading." I love the "luxury" feeling of putting on a serum before bed, too. Not irritating to my skin. If I get a slight dryness on the apple of my cheeks, I'll skip a night. I use it under my eyes with no problem.

  12. Margaret
    Reviewed on Monday, May 13, 2013
    20 out of 100
    • Rating
      Worst / 4
    Not For Me!
    • Tried free sample with purchase. Used this under my eyes and within 5 - 10 min, it started burning and got really red! Washed off immediately, but still hurts next morning. Love all other Paulas Choice products, so I don't know what happened. :(

    Customer Service Response
    Replied on: Tuesday, May 14, 2013
    Thank you so much for your review. We are sorry to hear that this product wasn't a good fit for your skin. Many people are sensitive to retinol and can not use it. We recommend checking out our antioxidant serums that do not contain retinol as they are perfect for those whose skin cannot tolerate this ingredient.
    —Admin
  13. Danbi C.
    Reviewed on Sunday, May 12, 2013
    60 out of 100
    • Rating
      Neutral / 4
    Great Product...except..
    • My skin do feels soft after using this product and makeup applies better. At first it feels little greasy, but it goes away quickly, and it's not a bad kind of oily feeling. My only problem with it...and reason for it being 3 star is after I apply it, my whole face become red. It doesn't itch or anything like that, but I do feel slightly flushed and even though it goes away after awhile. I don't know reason for this, but I don't think I should reorder this which is shame.

  14. Suzanne M.
    Reviewed on Saturday, May 11, 2013
    80 out of 100
    • Rating
      Good / 4
    Love this product!
    • This product is AMAZING! My face has never felt this soft. I love it! Thanks!

  15. Laura T
    Reviewed on Friday, May 10, 2013
    100 out of 100
    • Rating
      Best / 4
    Ditched my prescription tretinoin for this
    • I used to use prescription tretinoin to combat wrinkles, but I had to limit it to once every two or three days because it would cause peeling. I've since ditched that for this retinol serum. It may not be prescription-strength, but I can use it every night, and perhaps for that reason I've seen MUCH better results. My smile lines (around mouth and eyes) have almost completely disappeared! And the texture of my skin is visibly improved everywhere I use it: face, neck, chest and backs of hands.

  16. ROSEMARY r.
    Reviewed on Monday, May 06, 2013
    100 out of 100
    • Rating
      Best / 4
    too oily? try it elsewhere
    • I have oily cheeks & nose, but really combination skin. When this product came in, it proved too heavy for my face, but I simply LOVE using it everyday on my neck & upper chest. Ladies, look at the necks of women over 50 & see a place that has been ignored, even when wrinkles are taken seriously on the face. This works great for my neck & chest & I saw a difference in a couple of weeks. Ladies, our necks are crying for Retinol attention!

  17. Anonymous
    Reviewed on Thursday, May 02, 2013
    40 out of 100
    • Rating
      Poor / 4
    Not for me
    • This is one of the few products that had significantly made my skin worse after using. I alternated the product with RESIST Ultra Light Antioxidant Serum only to see an increase in breakouts and generally bad looking skin. I assume it was too much for my sensitive skin. I have it packed up to return for a refund.

  18. Jessica
    Reviewed on Thursday, May 02, 2013
    40 out of 100
    • Rating
      Poor / 4
    So sad it didn't work for me!
    • I received this as a free sample with my last order. I used it for 3 nights, then had to discontinue because it left some areas of my skin irritated and red, and the skin is now flaking a bit. Even after not using for two days, my skin still hurts. I am so sad because it felt great going on the first three nights and I thought it would work for me, but I guess it was too strong.

    Customer Service Response
    Replied on: Tuesday, May 07, 2013
    Thank you for your review, and we're sorry to learn of your experience! It's tricky with potent retinol products, as not everyone can tolerate their use. It sounds as if this formulas was too strong for you in daily use (for some, alternating days is a better fit). Be sure to contact our Customer Care Department via phone or email with any questions.
    —Admin
  19. kris
    Reviewed on Sunday, April 28, 2013
    100 out of 100
    • Rating
      Best / 4
    A hidden gem
    • I would have probably never purchased this product on my own but, it was sent as a free sample with my order. The ingredients are amazing and has done wonders for my skin! Will be buying the full size with my next order. Sits very nicely on skin and not heavy or irritating at all! I also love the packaging of this product! I think all the serums should be packaged this way. This is a product that anyone could use in there routine. Excellent job.

  20. CT
    Reviewed on Friday, April 26, 2013
    100 out of 100
    • Rating
      Best / 4
    A Believer
    • I generally don't write reviews but products generally don't perform how this Retinol Serum did. I'm 29 with minimal surface wrinkles and mild acne along with many old acne spots (red marks). When I first started to use this product I did break out a little bit. By week three I can honestly say I don't remember a time in my adult life where my skin has looked this good. My skin is soft, break out free and my red marks are fading. This product works.

  21. Anne K.
    Reviewed on Wednesday, April 24, 2013
    60 out of 100
    • Rating
      Neutral / 4
    Not the best for everyone
    • I was delighted to receive a free sample of this product and enthusiastically put it to use in my nightly routine. The texture is beautiful and it felt silky when I applied it around my eyes in the evening. However, after about two weeks and several sunny days, I woke up with dry, red, flaky patches in the areas where I applied it. I'll pass it along to someone with hardier skin (mine is pretty sensitive) and try another--I know Paula's got the right product for me, I just need to find it!

  22. Karen S.
    Reviewed on Tuesday, April 23, 2013
    40 out of 100
    • Rating
      Poor / 4
    Resist Intensive Wrinkle Repair Retinol Serum
    • I did not like the feel of this on my skin. I used it for 2 months now and don't see any improvement in my skin. In fact my skin looked better with my drugstore Retinol.

    Customer Service Response
    Replied on: Tuesday, May 07, 2013
    Thank you for your review, and we're sorry this wasn't a fit for you! Be sure to contact our Customer Care Department via phone or email. They would be happy to assist with a credit or exchange.
    —Admin
  23. Diane Ali
    Reviewed on Monday, April 22, 2013
    100 out of 100
    • Rating
      Best / 4
    Best Ever
    • I am at my 4th or 5th bottle. I use Paula"s Choice for over 2 years, I am amazed by all the products. I use everything for my type of skin-from skincare, sun care to make up. I am still crazy about all products I use. This serum is the best I ever used; I use it all over my face and eyes-it's that Great! It's smooth and makes my face feel prefect, fine lines disappear. Don't ever stop to make this Great product Paula. Thank you!

  24. ANG
    Reviewed on Sunday, April 21, 2013
    100 out of 100
    • Rating
      Best / 4
    Shocked!
    • Shocked at how much I love this product. I only started using it because my past order came with a free sample. In the past I always had too much irritation and too little results from Retinol products, so I almost didn't even try it. However, it felt great from day one and I have had NO redness or irritation at all! My skin seems smoother and clearer too (I don't really have wrinkles yet, so nothing to report there).

  25. MILES G.
    Reviewed on Friday, April 19, 2013
    100 out of 100
    • Rating
      Best / 4
    Effective, as promised!
    • This is an elegant serum, loaded with retinol and antioxidants. The product is effective as-is, but packs an even bigger punch when used after I cleanse with a popular sonic cleansing tool on the market today. I can practically feel the nutrients seep into my skin. Love, love, love the Wrinkle-Repair Retinol Serum.

Page of 12 Next »

What makes this product unique?
Paula's Choice RESIST Intensive Wrinkle-Repair Retinol Serum is an exclusive formula that utilizes a proprietary blend of highly stabilized retinol, potent antioxidants, and skin-repairing ingredients. Its soothing, silky texture goes to work immediately to help skin of any age look and act younger. With ongoing use, you will see fewer wrinkles, smoother skin, and improved skin tone.

This product is 100% fragrance- and colorant-free.

Who is this product for?
Anyone concerned with improving the appearance of aging skin and helping sun-damaged skin repair itself so it functions in a younger, healthier manner. Ideal for use with Paula's Choice RESIST line of anti-aging products. May be alternated with our best-selling RESIST Super Antioxidant Concentrate Serum.

Sources to support the claims made for RESIST Intensive Wrinkle-Repair Retinol Serum

Duodecim, Volume 128, Issue 22, 2012, pages 2,327–2,335; Journal of the European Academy of Dermatology and Venereology, September 2011, ePublication; Experimental Dermatology, July 2011, pages 572–576; Journal of Drugs in Dermatology, June 2011, pages 614–620; Fitoterapia, March 2011, pages 208–211; Lipids, September 2010, pages 833–841; Oxidative Medicine and Cellular Longevity, January-February 2010, pages 35–43; The Journal of Dermatological Treatment, May 2009, pages 276–281; Journal of the Indian Medical Association, April 2009, pages 219–222; American Journal of Clinical Dermatology, June 2008, pages 369–381; International Journal of Cosmetic Science, June 2008, pages 175–182; Journal of Dermatological Science, May 2008, pages 99–107; Archives of Dermatology, May 2007, pages 606–612; and Clinical Interventions in Aging, April 2006, pages 327-348.

Key Ingredients: retinol, caprylic/capric triglyceride, squalane, licorice extract, cell-communicating ingredients, Avena sativa, Laminaria ochroleuca extract, bisabolol, lecithin, palm oil, vitamin C, anti-irritant, antioxidant, vitamin E, kelp extract

Product Ingredients:

Cyclopentasiloxane, Dimethiconol (silicone slip agents/suspending agents), Neopentyl Glycol Diheptanoate (skin-conditioning agent), Dicaprylyl Carbonate (emollient), Caprylic/Capric Triglyceride (skin-repairing ingredient), Phenyl Trimethicone (silicone slip agent), Squalane (emollient), Bisabolol (anti-irritant), Tetrahexyldecyl Ascorbate (stabilized vitamin C/antioxidant), Retinol (cell-communicating ingredient/antioxidant), Tocotrienols (vitamin E-based antioxidant), Tocopherol (vitamin E/antioxidant), Lecithin (cell-communicating ingredient), Laminaria Ochroleuca (Kelp) Extract (anti-irritant), Avena Sativa (Oat) Kernel Oil (anti-irritant), Elaeis Guineensis (Palm) Oil (skin-repairing ingredient), Stearyl Glycyrrhetinate (licorice-derived anti-irritant), Hexylene Glycol (slip agent), Caprylyl Glycol (emollient), Ethylhexylglycerin (skin-conditioning agent), Phenoxyethanol (preservative).

DIRECTIONS: Apply in the evening after cleansing, toning, and exfoliating. Smooth a few drops onto skin before or after moisturizing. Perfect for use around the eyes. May be alternated with Paula’s Choice RESIST Super Antioxidant Concentrate Serum.

Detailed instructions on how/when to apply your Paula's Choice products can be found in our How to Put Together Your Own Skin-Care Routine article.

How does RESIST Intensive Wrinkle-Repair Retinol Serum differ from the other Antioxidant Concentrates that Paula's Choice offers?

The most notable difference is that RESIST Intensive Wrinkle-Repair Retinol Serum contains a higher amount of retinol than our Skin Recovery and Skin Balancing serums with retinol. The RESIST Super Antioxidant Concentrate Serum does not contain retinol and as such is an excellent serum to alternate with the Intensive Wrinkle-Repair Retinol Serum.  Both of the RESIST serums were designed for all skin types, whereas Skin Recovery Super Antioxidant Concentrate Serum is best for normal to very dry skin and Skin Balancing Super Antioxidant Mattifying Concentrate is best for normal to oily or combination skin.

Every Paula's Choice Super Antioxidant Concentrate Serum is silicone-based and contains an effective blend of antioxidants, skin-repairing ingredients, and cell-communicating ingredients to restore skin and significantly reduce wrinkles, increase collagen production, and improve skin color.

Which Paula's Choice serum should I use?

All skin types can use any of our serums, but there are some formulary distinctions that make certain Paula's Choice serums preferred for specific skin types. Here's how they break down:

  • RESIST Super Antioxidant Concentrate Serum and RESIST Intensive Wrinkle Repair Retinol Serum can be used by all skin types, including sensitive skin.
  • Skin Recovery Super Antioxidant Concentrate Serum is best for normal to very dry skin because it contains plant oils.
  • Skin Balancing Super Antioxidant Concentrate is best for normal to oily or combination skin because it has the lightest texture and weightless finish.
  • RESIST Super Antioxidant Concentrate Serum is one of two Paula’s Choice serums that does not contain retinol. It’s the natural choice for anyone whose skin cannot tolerate retinol.
  • RESIST Ultra-Light Super Antioxidant Concentrate Serum has the lightest texture of all the RESIST serums and is our only water-based (rather than silicone-based) serum. It does not contain retinol, so is recommended for those whose skin cannot tolerate this ingredient (or it may be used with one of our retinol serums).

Is RESIST Intensive Wrinkle-Repair Retinol Serum better than the other Paula's Choice serums?

Not better, just different. Think of it like broccoli and carrots: both are good for you but provide different nutritional benefits your body needs to be healthy. RESIST Intensive Wrinkle-Repair Retinol Serum was formulated with a greater amount of retinol to provide a higher degree of wrinkle repair—but all Paula's Choice serums contain an array of ingredients proven to help repair wrinkles and other signs of aging.

Can I use two Paula's Choice products with retinol, such as RESIST Barrier Repair Moisturizer with RESIST Intensive Wrinkle-Repair Retinol Serum?

Yes, this is fine; however, if you noticed that applying such products at the same time causes signs of irritation (such as redness or flaking) it would be best to apply one in the morning and the other at night, or consider switching to RESIST Super Antioxidant Concentrate Serum, which is retinol-free.

Can I use RESIST Intensive Wrinkle-Repair Retinol Serum with my prescription retinoid product (examples: Renova, Retin-A, generic tretinoin).

Yes, but generally speaking, you don't necessarily need to use retinol and a prescription retinoid. Many will do fine with one or the other, or you can apply the prescription retinoid at night and apply the retinol product during the day, always being sure to protect your skin with a product rated SPF 15 or greater. Keep in mind that using multiple retinoid products increases the risk of irritation, which is never the goal. With retinoids, more is not automatically better!

Can I apply RESIST Intensive Wrinkle-Repair Retinol Serum with a product medicated with benzoyl peroxide?

Yes. For best results, apply the benzoyl peroxide product to breakout-prone areas, allow to dry, then follow with RESIST Intensive Wrinkle-Repair Retinol Serum. Note that benzoyl peroxide should not be applied at the same time as the prescription retinoid tretinoin, as it renders this active ingredient ineffective. It does not appear to have this same effect on retinol.

What is the percentage of retinol in RESIST Intensive Wrinkle-Repair Retinol Serum?

Paula's Choice does not reveal the exact percentage of ingredients in any of our products except in the case of over-the-counter drug ingredients such as sunscreen actives and for our exfoliants. In these instances, knowing the exact percentage (or range) is critical as it impacts efficacy.

With retinol, amounts from 0.1–1% have proven to be effective, though higher amounts are known to increase the risk of side effects such as redness, sensitivity, and flaking. RESIST Intensive Wrinkle-Repair Retinol Serum contains an amount of retinol that's greater than our other serums with retinol. All Paula's Choice serums with retinol are formulated with stabilized retinol within the range of what research has shown to be effective for reducing wrinkles, improving skin tone, and building collagen.

Can I layer Paula's Choice serums? Do I need to do this?

Yes, you can and it does not matter which serum is applied first. Experiment to see which order of serum application works best for you. Although it's fine to layer our serums, ultimately you do not need to do this because every Paula's Choice serum treats skin to an array of brilliant ingredients. Because layering two serums plus your daytime moisturizer may feel too heavy under makeup, we recommend those who wish to layer our serums do so at night.

What makes RESIST Intensive Wrinkle-Repair Retinol Serum better than other retinol treatments?

RESIST Intensive Wrinkle-Repair Retinol Serum holds several advantages over other serums with retinol:

  • In addition to its targeted retinol formula, this serum also treats skin to a range of antioxidants, repairing ingredients, and anti-irritants. Each of these ingredients has published research showing how they improve aging skin.
  • The amount of retinol in this serum was expertly calibrated to ensure maximum efficacy without irritation. You're getting all of the benefits of retinol without bothersome side effects such as redness or flaking.
  • The chemist Paula chose to formulate this serum is a retinol expert who made sure every element of this targeted treatment was designed to improve wrinkles and signs of aging without tipping the scale toward irritation.
  • This retinol serum is packaged to ensure the efficacy and stability of the formula. The retinol itself is carefully handled and never exposed to degrading light or oxygen at any time during manufacturing.  The RESIST Intensive Wrinkle-Repair Retinol Serum requires specially designed packaging to keep this amount of retinol stable (droppers, pads or tubes would compromise the retinol's effectiveness). That means the serum you receive can deliver the full, pure potency of retinol.
  • You can rely on Paula and her Product Development team to provide the most advanced formulas at reasonable prices!

At what point after my laser and/or peel procedure can I begin using my serum again?

First, we urge you to follow the post-procedure instructions your doctor or nurse provided. If nothing was mentioned about when to resume use of a serum, please contact the doctor's office where you had the procedure done. Otherwise, our general advice is to begin using your serum again as soon as possible. All of our serums contain skin-repairing, anti-inflammatory, and replenishing ingredients that calm reddened skin and help enhance the healing process. Make sure you're also protecting your "new" skin every day with a product rated SPF 15 or greater.

Is RESIST Intensive Wrinkle-Repair Retinol Serum suitable for those with rosacea?

Yes. Research has shown that retinol can reduce inflammation that leads to symptoms of rosacea. The other antioxidants and soothing agents in this serum will help calm redness and soothe skin as they deliver anti-aging benefits.

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