CLINICAL 1% Retinol Treatment
Based on 490 reviews
A potent and uniquely formulated retinol solution that hydrates and delivers remarkable anti-aging benefits with a controlled-release delivery system to allow for even, consistent absorption.

CLINICAL 1% Retinol Treatment

Based on 490 reviews
A potent and uniquely formulated retinol solution that hydrates and delivers remarkable anti-aging benefits with a controlled-release delivery system to allow for even, consistent absorption.
  • Advanced hydrating complex absorbs quickly
  • Diminishes the appearance of wrinkles, fine lines
  • Light lotion texture delivers powerful results
  • Use after cleansing, toning & exfoliating skin
Skin Types:
All Skin Types
Wrinkles, Anti-Aging


    1 oz
    Travel Size...
Why is it different?
Combined with potent antioxidants, CLINICAL 1% Retinol Treatment is a specially formulated light lotion that absorbs quickly and goes to work immediately to enhance hydration and diminish the appearance of wrinkles, fine lines, and uneven skin tones. Licorice, oat extract and other soothing ingredients help to calm redness.
What does it do?
Goes to work immediately to visibly refine pore size and diminish the appearance of wrinkles, fine lines and uneven skin tone. The light lotion formula is supplemented with nourishing licorice extract, oat extract and other soothing plant extracts to calm skin and ease redness. You’ll be amazed at how much younger-looking, firmer, and radiant your skin will look and feel.
How to use

Limit initial use to three times per week; gradually increase frequency to every other night, then finally each evening as tolerated. Apply a pea-sized amount amount after cleansing and toning. Carefully avoid the lips, eyes (including eyelids) and corners of the eyes. Can be used on the perimeter of the orbital bone if desired. To minimize irritation, try combining with 2-3 drops of Resist Moisture Renewal Oil Booster.

Note: Some people may experience a delayed sensitized reaction to 1% retinol. Do not assume that if no reaction is seen after a few applications that you can apply this product more frequently. Pay close attention to how your skin responds and adjust usage accordingly.

If sensitization occurs (redness, flaking, tenderness, or drying of skin), reduce frequency of use or mix one pump of the Clinical 1% Retinol Treatment with your favorite Paula’s Choice serum or PM moisturizer. If sensitization persists, discontinue use. Protect skin daily with sunscreen rated SPF 30 or greater.

Show details

Journal of Cosmetic Dermatology, March 2016, issue 1, pages 49-57

Journal of Drugs in Dermatology, March 2015, issue 3, pages 271-280

Phytotherapy Research, August 2015, issue 8, pages 1117-1122

Skin Research and Technology, August 2013, issue 3, pages 291-298

Inflammopharmacology, October 2011, issue 5, pages 245-254

Journal of Cosmetic Dermatology, December 2008, issue 4, pages 281-289

Indian Journal of Dermatology and Venereology, March-April 2012, issue 2, pages 142-145

American Journal of Clinical Dermatology, 2003, issue 2, pages 107-129

Evidence Based Complementary Alternative Medicine, 2013, volume 2013, article 827248

Pharmacology and Physiology, March-April 2005, issue 2, pages 81-87

Dermato-Endocrinology, July 2012, issue 3, pages 253-258

Indian Dermatology Online Journal, April-June 2013, issue 2, pages 143-146

Product Ingredients

Water (Aqua), Dimethicone (skin-softening), Glycerin (skin-replenishing), Butylene Glycol (hydrating), Isononyl Isononanoate (emollient), Castor Isostearate Succinate (skin-softening ), Glyceryl Stearate (texture enhancer), C12-15 Alkyl Benzoate (emollient), Dimethicone Crosspolymer (texture enhancer), PEG-33 (stabilizer), Polysorbate 20 (texture enhancer), Behenyl Alcohol (texture enhancer), PEG-100 Stearate (texture enhancer), Pentaerythrityl Tetraisostearate (stabilizer), Polymethylsilsesquioxane (texture enhancer), Tetrahexyldecyl Ascorbate (vitamin C/antioxidant), Retinol (skin-restoring), Ceramide NG (skin-replenishing) , Palmitoyl Tetrapeptide-7 (skin-restoring), Palmitoyl Hexapeptide-12 (skin-restoring), Sodium Hyaluronate (skin-replenishing ), Dipotassium Glycyrrhizate (antioxidant plant extracts/skin-soothing), Glycyrrhiza Glabra Root Extract (licorice extract/antioxidant/skin-soothing), Avena Sativa Kernel Extract (oat extract/antioxidant/skin-soothing), Arctium Lappa Root Extract (burdock extract/antioxidant/skin-soothing), Salix Alba Bark Extract (willow bark extract/antioxidant/skin-soothing), Glycine Soja Sterols (antioxidant/skin-softening ), Lecithin (skin-restoring), Allantoin (skin-soothing), Tocopheryl Acetate (vitamin E/antioxidant), Hydrolyzed Soy Protein (antioxidant/skin-softening), Sorbitan Laurate (texture enhancer), Acetyl Dipeptide-1 Cetyl Ester (skin-soothing), Disodium EDTA (stabilizer), Hydroxyethylcellulose (texture enhancer), Palmitoyl Tripeptide-1 (skin-restoring), Sodium Hydroxide (pH adjuster), Tribehenin (emollient), Caprylyl Glycol (skin-softening), Ethylhexylglycerin (skin-softening), Pentylene Glycol (hydrating), PEG-75 Shea Butter Glycerides (emollient), PPG-12/SMDI Copolymer (stabilizer), PEG-10 Phytosterol (fatty acid-based emollient), PEG-8 Dimethicone (skin-softening), PEG-14 (texture enhancer), Magnesium Aluminum Silicate (texture enhancer), Arachidyl Glucoside (texture enhancer), Arachidyl Alcohol (texture enhancer), Sclerotium Gum (texture enhancer), Carbomer (gel-based texture enhancer), Phenoxyethanol (preservative), Benzoic Acid (preservative).

Ratings & Reviews



This retinol is wonderful! If I could afford the full size bottle I would get it! However, until that day I buy the travel size and use it once a week (or as spot treatment for acne). I have sensitive, dry, breakout-prone skin and this retinol smooths and brightens my skin.


Boston, MA


Will not go without this ever again


I am typically not a person that leaves reviews, but this one is worth reviewing!! This product is a game-changer. Before, I was using a retinol that was $110 for three months. This one is SO MUCH better and cheaper!!! Definitely worth the price. My skin is GLOWING and so smooth. It will go through phases where your skin peels (mine does this about every three weeks) but I just use more moisturizer. With this, I almost never wear face makeup, and if I do, it is very little. I have always struggled with breakouts and acne scarring, but this product is helping it so much!!




I would recommend this to others!


I struggled with redness and acne scars so I thought I'd give this product a try. I was skeptical at first so I just bought the travel size, but just that small tube did wonders. So of course when I ran out I bought the normal size of this product and my skin has never looked better.


Cuba, MO




I bought the sample size a month ago and even though it takes about 3 months for results to show, I see a difference in my skin already. I'm hoping that in 3 months or more I see a reduction in the wrinkles around my mouth. I started out slow (every other night) and now I use it every night with my usual AHA routine and so far this product has not irritated my skin or caused redness. I understand retinol takes awhile before you see any results, but so far I am happy with this product and will continue to use it regularly.


Jersey Shore


Best OTC Retinol on the market!


This has been my go to, holy grail retinol product for about 3 years. I have oily, acne prone, sensitive skin which I'm sure you can imagine comes with complications. PC products are skin care super stars. It took me some time, some, trial and error but now I have the perfect routine that works for me and this retinol is essential to that. It is rich but it absorbs quickly and has never caused blocked pores or breakouts. I suggest if you have oily skin to apply in very, very small amounts in patting motions. Instead of rubbing the product in, use your ring finger to pat and again use a very small amount for each section of your face. I apply this under my eyes and everywhere with no irritation. When originally applying for the first time, if I remember correctly I used it once every 2 days then graduated the amount on a bi-weekly basis. I apply it every night now but only bc MY SKIN CAN TOLERATE that frequency. PC just released a retinol booster and I'm buying that today just bc I'm curious as to how it works and what the differences are if any. I also want to see if any improvement happens. All in all PC's Clinical 1% retinol is worth your time and worth trying.


Mobile, Alabama


My first retinol experience


I'm 27 and just recently started to up my skincare game. I have been a smoker for half my life so my skin isn't as youthful as should be at my age. Anyway, this is more of a first impression review since I have only used it twice. Definitely mix with half parts lotion if is your first time because my skin flaked off even with diluting it. At first I regretted using it because my skin was so sensitive and I couldn't use any active ingredients or acids on my it for 3 days.I also looked a bit sunburnt. But after the initial sensitivity went down I noticed how much my skin was glowing. My main concerns are textured skin and fine lines. It hasn't helped the lines much yet but my skin is really smooth. My pores are smaller. This is the first time I have used a skincare product that actually delivered really noticeable results so fast. My advice would be to spend the $11 for the trial size. It's super tiny but you don't need a lot in the beginning anyway. It also is still in a safe pump container. Just a super tiny one. I just wish all of Paula's products were available in the travel size.


Baltimore, MD


Best product ever!!!!


My skin has a healthy glow and feels so youthful ... Please always make this available because it works and I can say with honesty that I will only spend this amount on your product because it works I don't like to spend money on any products that don't pass my strict test... I stock up when you give really deals like 40% off I cant wait for some xmas sales please make to have this item on sale more and me and my sis and mom will stock up love you Paula your the best ...

Jenna lovely rose

Rhode Island


This Retinal product works


Love it, it did not irritate my skin. I also mix it with any serum, don;t put it directly to my skin. I can see a great result.


Sausalito Ca


Love it


It is really hard to say that a particular product works, since I use a lot and different brands. But with this one, that I apply at night, I see the difference the next morning. My skin is so smooth and silky, unbelievable. Definitely a must have!




Amazing treatment with great results


The CLINICAL 1% Retinol is one of the best treatments I have tried, making my skin looking better almost instantly. It plumps and makes my skin smooth, minimizing the look of my fine lines (forehead, smile lines). I don't find it hydrating, I use it with a good moisturizer. I have tried other retinol treatments and while they help, nothing has the same amazing results for my skin like this one. I have combination skin, some dry patches (especially in cold weather) and a good tolerance to retinol (I use it 3-4 times a week). I actually prefer the travel size, I can finish the big bottle in one year.

Ana, P.

Santa Clara, CA


CLINICAL 1% Retinol Treatment

4.3 490