Adenosine at a Glance
- Derived from yeast as a skin care ingredient (but also naturally present in the body)
- Topical application connects to skin’s natural adenosine receptors
- Known for its anti-wrinkle, skin-smoothing, and soothing benefits
- Also shows potential for its healing properties
- White, odorless, crystalline powder in its raw form
Adenosine is a water-soluble yeast-derived ingredient that functions as a good soothing and skin-restoring agent. It has proven anti-wrinkle benefits and is a safe, beneficial ingredient all skin types can use. Studies also indicate strong potential for soothing properties.
One of the particularly exceptional qualities of adenosine is that it’s a natural component of the body and its receptors have specifically been identified in skin cells, allowing for a direct connection and impressive effectiveness when applied topically.
In one study (conducted by L’Oreal) adenosine showed efficacy in as low as 0.1% concentration for improving deep wrinkles in the periorbital area (i.e. crow’s feet) as well as glabellar frown lines (known as the 11s between brows).
In 2020, the Expert Panel for Cosmetic Ingredient Safety concluded that adenosine was safe in concentrations of up to 1% in leave on skin care products.
Adenosine is described as a white, odorless, crystalline powder in its raw form.
PubChem, Accessed May 2021, ePublication
Cosmetic Ingredient Review, September 2020, pages 1-38
Experimental Dermatology, August 2014, pages 553-554
Journal of Investigative Dermatology, August 2011, pages 526-546
International Journal of Cosmetic Science, December 2006, pages 447-451
British Journal of Pharmacology, October 2008, issue 4, pages 475-486
PloS One, May 2008 (ePublication) International Journal of Cosmetic Science, August 2006, pages 447-451
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About the Experts
Paula Begoun is the best-selling author of 20 books about skincare and makeup. She is known worldwide as The Cosmetics Cop and creator of Paula’s Choice Skincare. Paula’s expertise has led to hundreds of appearances on national and international radio, print, and television including:
The Paula's Choice Research Team is dedicated to busting beauty myths and providing expert advice that solves your skincare frustrations so you can have the best skin of your life!