I am not one to say that something works "immediately" or "overnight" because I believe products take awhile to have an effect. HOWEVER, I called the Paula's Choice advisor line to ask for input about the sides of my nose. They have always been dry and flaky despite the rest of my facial skin looking beautiful. I use the same Paula's Choice routine on that area — but my makeup cakes and flakes. The advisor recommended this serum. WOWZER. I applied it the morning after I received it to sides of my nose and under my eyes. IMMEDIATELY my foundation went on smoothly. I've had no flakiness since using this twice/day (AM and PM) — and this is after 10-15 years of the problem. I also see improvement in thin flakiness under my eyes, esp near the corners where concealer can cake. This is a miracle product — I absolutely LOVE it.