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I was having issues with a dry and very flaky spot along the side of my nose. I started a better skin care routine using Paula's Choice products for the most part. It is likely the whole combination led to getting rid of the flaky dry spot within one week. This serum was part of my nighttime routine. After cleansing, I used RESIST Advanced Replenishing toner. I exfoliate in the morning, so I go straight to using the Omega+ Complex serum. Then I follow up with the Anti-Aging Clear Skin Hydrator. This coupled with a morning routine of cleansing, 2% BHA gel, Hyaluronic Acid Booster, and moisturizer with sunscreen seems to have done the trick in removing the dry patch. Definitely going to keep at this routine to keep the dry patches at bay. It's tricky, because my cheeks and chin and sometimes my forehead tend to get some acne (even at 47), so I have to keep the superhydrating moisturizer off those areas. I finish up those areas with the lightweight RESIST Youth-Extending Daily Hydrating Fluid SPF 50.